The Role of SNHG15 in the Pathogenesis of Hepatocellular Carcinoma

Christos Damaskos^{1

2}, Nikolaos Garmpis^{2

3}, Dimitrios Dimitroulis³, Anna Garmpi⁴, Evangelos Diamantis⁵, Panagiotis Sarantis⁶, Vasiliki E Georgakopoulou⁷, Alexandros Patsouras⁸, Markos Despotidis⁹, Dionysios Prevezanos¹, Athanasios Syllaios⁹, Georgios Marinos¹⁰, Evangelos Koustas⁶, Christos Vallilas⁶, Efstathios A Antoniou^{2

3}, Konstantinos Kontzoglou^{2

3}, Spyridon Savvanis¹¹, Gregory Kouraklis¹²

Affiliations

¹ Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece.
² N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
³ Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁴ First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁵ Endocrinology Unit, Academic Department of Internal Medicine, Agioi Anargyroi General Oncology Hospital, National and Kapodistrian University of Athens, 14564 Kifisia, Greece.
⁶ Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁷ Department of Pulmonology, Laiko General Hospital, 11527 Athens, Greece.
⁸ Second Department of Pulmonology, Sotiria Hospital, 11527 Athens, Greece.
⁹ First Department of Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
¹⁰ Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
¹¹ Internal Medicine Department, Elpis General Hospital, 11522 Athens, Greece.
¹² Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

PMID: 35629174
PMCID: PMC9145272
DOI: 10.3390/jpm12050753

Review

The Role of SNHG15 in the Pathogenesis of Hepatocellular Carcinoma

Christos Damaskos et al. J Pers Med. 2022.

. 2022 May 6;12(5):753.

doi: 10.3390/jpm12050753.

Authors

Affiliations

¹ Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece.
² N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
³ Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁴ First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁵ Endocrinology Unit, Academic Department of Internal Medicine, Agioi Anargyroi General Oncology Hospital, National and Kapodistrian University of Athens, 14564 Kifisia, Greece.
⁶ Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁷ Department of Pulmonology, Laiko General Hospital, 11527 Athens, Greece.
⁸ Second Department of Pulmonology, Sotiria Hospital, 11527 Athens, Greece.
⁹ First Department of Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
¹⁰ Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
¹¹ Internal Medicine Department, Elpis General Hospital, 11522 Athens, Greece.
¹² Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

PMID: 35629174
PMCID: PMC9145272
DOI: 10.3390/jpm12050753

Abstract

Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides which cannot be translated into proteins. Small nucleolar RNA host gene 15 (SNHG15) is a lncRNA whose dysregulation has been found to have an important impact on carcinogenesis and affect the prognosis of cancer patients in various cancer types. Hepatocellular carcinoma (HCC) is one of the most common cancers with a poor long-term prognosis, while the best prognostic factor of the disease is its early diagnosis and surgery. Consequently, the investigation of the mechanisms of hepatocarcinogenesis, as well as the discovery of efficient molecular markers and therapeutic targets are of great significance. An extensive literature search was performed in MEDLINE in order to identify clinical studies that tried to reveal the role of SNHG15 in HCC. We used keywords such as 'HCC', 'hepatocellular carcinoma', 'SNHG15' and 'clinical study'. Finally, we included four studies written in English, published during the period 2016-2021. It was revealed that SNHG15 is related to the appearance of HCC via different routes and its over-expression affects the overall survival of the patients. More assays are required in order to clarify the potential role of SNHG15 as a prognostic tool and therapeutic target in HCC.

Keywords: SNHG15; cancer; carcinoma; hepatocarcinogenesis; hepatocellular; lncRNA.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
PRISMA flow diagram for the current article process.

**Figure 2**
Effects of SNHG15 on hepatocellular carcinoma.

See this image and copyright information in PMC

References

1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
1. Dimitroulis D., Damaskos C., Valsami S., Davakis S., Garmpis N., Spartalis E., Athanasiou A., Moris D., Sakellariou S., Kykalos S., et al. From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world. World J. Gastroenterol. 2017;23:5282–5294. doi: 10.3748/wjg.v23.i29.5282. - DOI - PMC - PubMed
1. Zhu R.X., Seto W.K., Lai C.L., Yuen M.F. Epidemiology of hepatocellular carcinoma in the Asia-Pacific region. Gut Liver. 2016;10:332–339. doi: 10.5009/gnl15257. - DOI - PMC - PubMed
1. Garmpis N., Damaskos C., Garmpi A., Georgakopoulou V.E., Sarantis P., Antoniou E.A., Karamouzis M.V., Nonni A., Schizas D., Diamantis E., et al. Histone deacetylase inhibitors in the treatment of hepatocellular carcinoma: Current evidence and future opportunities. J. Pers. Med. 2021;11:223. doi: 10.3390/jpm11030223. - DOI - PMC - PubMed
1. El-Sherag H.B., Rudolph K.L. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557–2576. doi: 10.1053/j.gastro.2007.04.061. - DOI - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The Role of SNHG15 in the Pathogenesis of Hepatocellular Carcinoma

Affiliations

The Role of SNHG15 in the Pathogenesis of Hepatocellular Carcinoma

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

LinkOut - more resources

Full Text Sources