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Review
. 2022 Apr 22;12(5):383.
doi: 10.3390/metabo12050383.

Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review

Ionela Mihaela Vladu  1 , Diana Clenciu  1 , Adina Mitrea  1 , Anca Amzolini  2 , Simona Elena Micu  2 , Anda Elena Crisan  3 , Ion Cristian Efrem  4 , Maria Fortofoiu  5 , Mircea Catalin Fortofoiu  2 , Adrian Mita  2 , Anca Barau Alhija  2 , Adina Dorina Glodeanu  4 , Maria Mota  1
Affiliations
Review

Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review

Ionela Mihaela Vladu et al. Metabolites. .

Abstract

Gestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with genetic and epigenetic factors in the development of GDM. So far, several metabolomics studies have investigated metabolic disruptions associated with GDM. The aim of this review is to highlight the usefulness of maternal metabolites as diagnosis markers of GDM as well as the importance of both maternal and fetal metabolites as prognosis biomarkers for GDM and GDM's transition to type 2 diabetes mellitus T2DM.

Keywords: biomarkers; cardiovascular risk; gestational diabetes mellitus; metabolic pathways; metabolomics; obesity.

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Conflict of interest statement

The authors declare no conflict of interest.

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