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Case Reports
. 2022 Apr 29;58(5):618.
doi: 10.3390/medicina58050618.

Photobiomodulation Therapy in the Treatment of Oral Mucositis-A Case Report

Przemysław Jabłoński  1 , Mikołaj Musiał  2 , Rafał Wiench  3 , Natalia Stefanik  3 , Cyprian Olchowy  4 , Jacek Matys  4   5 , Dariusz Skaba  3 , Kinga Grzech-Leśniak  4   6
Affiliations
Case Reports

Photobiomodulation Therapy in the Treatment of Oral Mucositis-A Case Report

Przemysław Jabłoński et al. Medicina (Kaunas). .

Abstract

In 2021, our group published a laboratory study on the impact of PBM on human gingival fibroblasts. The in vitro results confirmed the fact that the appropriately selected wavelength and properly selected parameters of the laser settings can increase cell proliferation, modulate inflammatory markers, and decrease the susceptibility of human gingival fibroblasts to apoptosis. Therefore, this case report was aimed at the clinical evaluation of the proposed settings and treatment regimen in a very difficult situation of an immunocompromised patient with extensive changes and stagnation of symptoms for many weeks. A 65-year-old man, during his oncological treatment, was diagnosed with oral mucositis grade 3 according to the World Health Organization and National Cancer Institute scales. Due to pain sensation, long-lasting and not healing oral lesions, and problems with solid food intake, he was qualified for laser photobiomodulation therapy. For the management of oral lesions, a diode laser 635 nm (SmartMPro, Lasotronix, Poland) was intraorally applied at an energy density of 4 J/cm2, the 20 s of irradiation, the output power of 100 mW, and in continuous wave mode. Seven treatment procedures were performed two times a week using the spot technique in contact and non-contact mode. Within 21 days of monotherapy, all ailments disappeared. The patient was also able to reuse dental dentures and return to a solid diet. The obtained results confirm the efficiency of at least 3 PBM protocols. Our case shows that the use of PMB therapy contributes to faster healing of painful oral lesions in oncological patients, and thus the treatment time and return to the appropriate quality of life is shorter.

Keywords: cancer complications; diode laser; side effects; supportive cancer care.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Images of the extensive ulceration on the left lateral surface of the tongue, just before the 1st PBM procedure (A), during the 1st PBM (B), on the 4th day after the 1st irradiation, and before the 2nd PBM (C), on the 7th day before the 3rd PBM treatment (D), on the 14th day after the first treatment before the 5th PBM (E), and on the 21st day before the 7th and last PBM treatment (F).
Figure 2
Figure 2
Views of the ulcer on the right pharyngeal arch just before the 1st PBM procedure (A), on the 4th day before the 2nd PBM procedure (B), on the 7th day before the 3rd PBM (C), on the 14th day before the 4th PBM (D), and on the 21st before the 7th and last PBM treatment (E).
Figure 3
Figure 3
Views of the ulcer in the right labial commissure just before the 1st PBM treatment (A), on the 4th day before the 2nd PBM (B), on the 7th day before the 3rd PBM (C), on the 14th day before the 5th PBM (D), and on the 21st day before the 7th and last PBM treatment (E).
See this image and copyright information in PMC

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