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Review
. 2022 May 12;58(5):655.
doi: 10.3390/medicina58050655.

Pulmonary Coccidioidomycosis: A Case Report and Literature Review

Tadas Alčauskas  1 , Birutė Zablockienė  2 , Rolandas Zablockis  3 , Linas Svetikas  2 , Laura Bilotaitė  1 , Ligita Jančorienė  2
Affiliations
Review

Pulmonary Coccidioidomycosis: A Case Report and Literature Review

Tadas Alčauskas et al. Medicina (Kaunas). .

Abstract

Coccidioidomycosis is an infectious disease caused by Coccidioides immitis or C. posadasii fungus. Humans usually get infected by inhaling spores risen from the soil. Although in 60 percent of cases symptoms are absent, remaining patients can develop various manifestations of the disease, from flu-like symptoms to severe dissemination or meningitis. In endemic regions (California, Arizona, Mexico, Central, and South America), pulmonary coccidioidomycosis causes 25% of community-acquired cases of pneumonia. We present the first registered case of pulmonary coccidioidomycosis in Lithuania. Clinical presentation, pathogenesis, treatment options, and diagnostic alternatives are discussed.

Keywords: coccidioidomycosis; fluconazole; fungal infection.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Ultrasound of the abdomen showing hepatomegaly: liver diameter is 169.29 mm in the midclavicular line (normal range < 150.00 mm). (b) Ultrasound of the abdomen showing portal hepatic lymphadenopathy: lymph node dimensions 13.73 × 9.40 mm.
Figure 2
Figure 2
Frontal and lateral chest X-rays showing dynamics of the infiltration in the basal segment of the right lung.
Figure 3
Figure 3
Fibrobronchoscopy showing multiple nodules in the trachea.
Figure 4
Figure 4
The dynamics of control CT scans before treatment and after 12 months of treatment.
Figure 4
Figure 4
The dynamics of control CT scans before treatment and after 12 months of treatment.
See this image and copyright information in PMC

References

    1. Thompson G., Brown J., Benedict K., Park B.J. Coccidioidomycosis: Epidemiology. Clin. Epidemiol. 2013;5:185–197. doi: 10.2147/CLEP.S34434. - DOI - PMC - PubMed
    1. Stockamp N.W., Thompson G.R., 3rd Coccidioidomycosis. Infect. Dis. Clin. N. Am. 2016;30:229–246. doi: 10.1016/j.idc.2015.10.008. - DOI - PubMed
    1. Matlock M., Hopfer S., Ogunseitan O.A. Communicating Risk for a Climate-Sensitive Disease: A Case Study of Valley Fever in Central California. Int. J. Environ. Res. Public Health. 2019;16:3254. doi: 10.3390/ijerph16183254. - DOI - PMC - PubMed
    1. Sondermeyer G., Lee L., Gilliss D., Tabnak F., Vugia D. Coccidioidomycosis-associated Hospitalizations, California, USA, 2000–2011. Emerg. Infect. Dis. 2013;19:1590–1597. doi: 10.3201/eid1910.130427. - DOI - PMC - PubMed
    1. Donovan F.M., Shubitz L., Powell D., Orbach M., Frelinger J., Galgiani J.N. Early Events in Coccidioidomycosis. Clin. Microbiol. Rev. 2019;33:e00112-19. doi: 10.1128/CMR.00112-19. - DOI - PMC - PubMed