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Review
. 2022 Apr 28;10(5):927.
doi: 10.3390/microorganisms10050927.

Do Triclosan Sutures Modify the Microbial Diversity of Surgical Site Infections? A Systematic Review and Meta-Analysis

Frederic C Daoud  1 , Maïder Coppry  1   2 , Nicholas Moore  1 , Anne-Marie Rogues  1   2
Affiliations
Review

Do Triclosan Sutures Modify the Microbial Diversity of Surgical Site Infections? A Systematic Review and Meta-Analysis

Frederic C Daoud et al. Microorganisms. .

Abstract

Randomised controlled clinical trials (RCTs) report a lower incidence rate of surgical site infections (SSIs) with triclosan sutures (TSs) compared with non-triclosan sutures (NTSs). Do triclosan sutures modify the microbial diversity of culture-confirmed SSIs (ccSSIs)? If so, this would support the association between TS antimicrobial activity and the SSI incidence rate. This prospective systematic literature review (PROSPERO CRD42019125099) was conducted according to PRISMA. RCTs that compared the incidence of SSIs with TSs and NTSs and reported microbial counts from SSI cultures per suture group were eligible. The microbial species were grouped by genus, and the association between genera and sutures was tested. The pooled relative risk (RR) of ccSSIs was also calculated. Twelve RCTs were eligible. No publication bias was identified. The microorganism count was 180 in 124 SSIs with TSs versus 246 in 199 SSIs with NTSs. No significant difference in microbial diversity was found, but statistical power was low for test results to support or challenge the association between the antimicrobial activity of TSs and the reduced rate of SSIs. The RR of the ccSSIs was significant and consistent with comprehensive meta-analyses. The certainty of the pooled RR was moderate.

Keywords: diversity; meta-analysis; microorganisms; surgical site infection; sutures; triclosan.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow chart.
Figure 2
Figure 2
Publication bias analysis—funnel plot.
Figure 3
Figure 3
Forest plot—pooled relative risk of ccSSIs and RCTs’ risk of bias [58,59,60,61,62,63,64,65,66,67,68,69].
Figure 4
Figure 4
Risk of bias summary of each RoB item as percentages across all included studies.
See this image and copyright information in PMC

References

    1. European Centre for Disease Prevention and Control Surveillance of Surgical Site Infections in European Hospitals–HAISSI protocol. Version 1.02. Stockholm: ECDC. 2012. [(accessed on 17 December 2019)]. Available online: http://ecdc.europa.eu/en/publications/Publications/120215_TED_SSI_protoc....
    1. WHO . Protocol for Surgical Site Infection Surveillance with a Focus on Settings with Limited Resources. World Health Organization; Geneva, Switzerland: 2018. [(accessed on 17 December 2019)]. Licence: CC BY-NC-SA 3.0 IGO. Available online: https://www.who.int/infection-prevention/tools/surgical/SSI-surveillance....
    1. European Centre for Disease Prevention and Control . Healthcare-Associated Infections: Surgical Site Infections. ECDC; Stockholm, Sweden: 2019. [(accessed on 17 December 2019)]. Annual Epidemiological Report for 2017. Available online: https://www.ecdc.europa.eu/sites/default/files/documents/AER_for_2017-SS....
    1. Mangram A.J., Horan T.C., Pearson M.L., Silver L.C., Jarvis W.R. The Hospital Infection Control Practices Advisory Committee Guideline for Prevention of Surgical Site Infection, 1999. Infect. Control Hosp. Epidemiol. 1999;20:250–278. doi: 10.1086/501620. - DOI - PubMed
    1. Centers for Disease Control and Prevention (CDC) An Introduction to Applied Epidemiology and Biostatistic. 3rd ed. Centers for Disease Control and Prevention; Atlanta, GA, USA: [(accessed on 20 March 2021)]. Principles of Epidemiology in Public Health Practice. Available online: https://www.cdc.gov/csels/dsepd/ss1978/index.html.

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