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. 2022 May 23;14(10):2172.
doi: 10.3390/nu14102172.

The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia

Alejandra Abascal-Saiz  1 , Marta Duque-Alcorta  2 , Victoria Fioravantti  3 , Eugenia Antolín  1 , Eva Fuente-Luelmo  4 , María Haro  4 , María P Ramos-Álvarez  4 , Germán Perdomo  5 , José L Bartha  1
Affiliations

The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia

Alejandra Abascal-Saiz et al. Nutrients. .

Abstract

Antiangiogenic factors are currently used for the prediction of preeclampsia. The present study aimed to evaluate the relationship between antiangiogenic factors and lipid and carbohydrate metabolism in maternal plasma and placenta. We analyzed 56 pregnant women, 30 healthy and 26 with preeclampsia (including early and late onset). We compared antiangiogenic factors soluble Fms-like Tyrosine Kinase-1 (sfLt-1), placental growth factor (PlGF), and soluble endoglin (sEng)), lipid and carbohydrate metabolism in maternal plasma, and lipid metabolism in the placenta from assays of fatty acid oxidation, fatty acid esterification, and triglyceride levels in all groups. Antiangiogenic factors sFlt-1, sFlt-1/PlGF ratio, and sEng showed a positive correlation with triglyceride, free fatty acid, and C-peptide maternal serum levels. However, there was no relationship between angiogenic factors and placental lipid metabolism parameters. Free fatty acids were predictive of elevated sFlt-1 and sEng, while C-peptide was predictive of an elevated sFlt1/PlGF ratio. The findings in this study generate a model to predict elevated antiangiogenic factor values and the relationship between them with different products of lipid and carbohydrate metabolism in maternal serum and placenta in preeclampsia.

Keywords: angiogenic markers; carbohydrate metabolism; correlation; esterification; gestational hypertension; lipid metabolism; oxidation; placental function; placental villous explants; triglyceride.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Linear regression with 95% confidence interval for prediction of angiogenic factor elevation (p < 0.05): (a) Elevation of free fatty acids (FFA) was a predictor for elevation of soluble fms-like tyrosine kinase-1(sFlt-1) (b) and soluble endoglin(sEng) (c) C-peptide was a predictor for high sFlt1/PlGF ratio. The control group is represented in black; the preeclampsia group is shown in red. The units of measurement for these parameters were: FFA (mg/dL), sFlt-1 (pg/mL), sEng (ng/mL), C-peptide (ng/mL). PIGF: placental growth factor.
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References

    1. Brown M.A., Magee L.A., Kenny L.C., Karumanchi S.A., McCarthy F.P., Saito S., Hall D.R., Warren C.E., Adoyi G., Ishaku S. The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens. 2018;13:291–310. - PubMed
    1. Poon L.C., Shennan A., Hyett J.A., Kapur A., Hadar E., Divakar H., McAuliffe F., da Silva Costa F., von Dadelszen P., McIntyre H.D., et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. Int. J. Gynaecol. Obstet. 2019;145((Suppl. 1)):1–33. doi: 10.1002/ijgo.12802. - DOI - PMC - PubMed
    1. Burton G.J., Redman C.W., Roberts J.M., Moffett A. Pre-eclampsia: Pathophysiology and clinical implications. BMJ. 2019;366:l2381. doi: 10.1136/bmj.l2381. - DOI - PubMed
    1. Phipps E.A., Thadhani R., Benzing T., Karumanchi S.A. Pre-eclampsia: Pathogenesis, novel diagnostics and therapies. Nat. Rev. Nephrol. 2019;15:275–289. doi: 10.1038/s41581-019-0119-6. - DOI - PMC - PubMed
    1. Redman C.W. Current topic: Pre-eclampsia and the placenta. Placenta. 1991;12:301–308. doi: 10.1016/0143-4004(91)90339-H. - DOI - PubMed

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