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Review
. 2022 Apr 22;15(5):518.
doi: 10.3390/ph15050518.

Radiopharmaceutical Labelling for Lung Ventilation/Perfusion PET/CT Imaging: A Review of Production and Optimization Processes for Clinical Use

Frédérique Blanc-Béguin  1 , Simon Hennebicq  1 , Philippe Robin  1 , Raphaël Tripier  2 , Pierre-Yves Salaün  1 , Pierre-Yves Le Roux  1
Affiliations
Review

Radiopharmaceutical Labelling for Lung Ventilation/Perfusion PET/CT Imaging: A Review of Production and Optimization Processes for Clinical Use

Frédérique Blanc-Béguin et al. Pharmaceuticals (Basel). .

Abstract

Lung ventilation/perfusion (V/Q) positron emission tomography-computed tomography (PET/CT) is a promising imaging modality for regional lung function assessment. The same carrier molecules as a conventional V/Q scan (i.e., carbon nanoparticles for ventilation and macro aggregated albumin particles for perfusion) are used, but they are labeled with gallium-68 (68Ga) instead of technetium-99m (99mTc). For both radiopharmaceuticals, various production processes have been proposed. This article discusses the challenges associated with the transition from 99mTc- to 68Ga-labelled radiopharmaceuticals. The various production and optimization processes for both radiopharmaceuticals are reviewed and discussed for optimal clinical use.

Keywords: 68Ga-labelled carbon nanoparticles; V/Q PET/CT; [68Ga]Ga-MAA.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Key points of MAA labelling with 68Ga.
Figure 2
Figure 2
Schematic representation of the [68Ga]Ga-MAA purification stage based on the process by Blanc-Béguin et al. Used with permission from Blanc-Béguin et al. [39].
See this image and copyright information in PMC

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