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Review
. 2022 May 12;10(5):766.
doi: 10.3390/vaccines10050766.

Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis

Petros Galanis  1 , Irene Vraka  2 , Olga Siskou  3 , Olympia Konstantakopoulou  3 , Aglaia Katsiroumpa  1 , Daphne Kaitelidou  3
Affiliations
Review

Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis

Petros Galanis et al. Vaccines (Basel). .

Abstract

Mass vaccination against COVID-19 is essential to control the pandemic. COVID-19 vaccines are now recommended during pregnancy to prevent adverse outcomes. With this review, we aimed to evaluate the evidence in the literature regarding the uptake of COVID-19 vaccinations among pregnant women. A comprehensive search was performed in PubMed, Medline, Scopus, ProQuest, Web of Science, CINAHL, and medRxiv from inception to 23 March 2022. We performed a meta-analysis to estimate the overall proportion of pregnant women vaccinated against COVID-19. We found 11 studies including 703,004 pregnant women. The overall proportion of pregnant women vaccinated against COVID-19 was 27.5% (95% CI: 18.8-37.0%). Predictors of COVID-19 vaccination uptake were older age, ethnicity, race, trust in COVID-19 vaccines, and fear of COVID-19 during pregnancy. Mistrust in the government, diagnosis of COVID-19 during pregnancy, and fears about the safety and side effects of COVID-19 vaccines were reasons for declining vaccination. The global COVID-19 vaccination prevalence in pregnant women is low. A large gap exists in the literature on the factors influencing the decision of pregnant women to be vaccinated against COVID-19. Targeted information campaigns are essential to increase vaccine literacy among pregnant women.

Keywords: COVID-19; predictors; pregnant women; uptake; vaccination.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart diagram of the systematic review.
Figure 2
Figure 2
Forest plot of pregnant women vaccinated against COVID-19.
See this image and copyright information in PMC

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