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. 2022 May 20;10(5):812.
doi: 10.3390/vaccines10050812.

COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study

Mario J Valladares-Garrido  1   2   3 , Sandra Zeña-Ñañez  4 , C Ichiro Peralta  5 , Jacqueline B Puicón-Suárez  6 , Cristian Díaz-Vélez  3   7 , Virgilio E Failoc-Rojas  3   8
Affiliations

COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study

Mario J Valladares-Garrido et al. Vaccines (Basel). .

Abstract

COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28-0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.

Keywords: COVID-19; Peru; mortality; vaccination; vaccine effectiveness.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Survival of patients hospitalized for COVID-19 according to vaccination status. (A) Survival after 28 days. (B) Survival after 90 days.
See this image and copyright information in PMC

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