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. 2022 Sep;34(9):2089-2098.
doi: 10.1007/s40520-022-02149-1. Epub 2022 May 28.

The effect of ageing on fat infiltration of thigh and paraspinal muscles in men

Klaus Engelke  1   2 , Mansour Ghasemikaram  3 , Oliver Chaudry  4 , Michael Uder  5 , Armin M Nagel  5 , Franz Jakob  6 , Wolfgang Kemmler  3   5
Affiliations

The effect of ageing on fat infiltration of thigh and paraspinal muscles in men

Klaus Engelke et al. Aging Clin Exp Res. 2022 Sep.

Abstract

Background: Myosteatosis, skeletal muscle fat infiltration, is associated with inflammation and fibrosis. The age-related increase of myosteatosis is an important characteristic of sarcopenia and contributes to fragility.

Aims: To investigate the impact of healthy aging on intermuscular adipose tissue (IMAT) and muscle fat fraction (FF) in the thigh and the paraspinal muscles in males.

Methods: In 54 healthy males (age 20-70), all active hobby golfers, magnetic resonance imaging was performed to determine volume of IMAT, volume of muscle tissue (MT) and of percentage of FF.

Results: Between ages 20-70, at the thigh, IMAT/MT volume and MT FF increased annually by 2.9% and 1.3%, respectively. At the psoas IMAT/Psoas volume did not change with age. MT FF increased by 1.5% annually. At the erector spinae IMAT/Erector volume decreased by 0.3% and MT FF increased by 2.8% annually.

Discussion: With increasing age, in males, thigh muscle atrophied, muscle tissue was partly replaced by adipose tissue and remaining muscle tissue also contained more fat. Similar effects were observed in the erector spinae. The psoas muscle did not atrophy, although MT FF also increased with age. Overall correlations with age were weak to moderate with higher correlations observed in the paraspinal muscles.

Conclusions: Age-related increases of muscle fat infiltration were observed in the thigh and in the spine. Muscle atrophy did not occur in the psoas. In cross-sectional studies, an adjustment of volumetric parameters by muscle volume is advisable when comparing age-dependent results.

Keywords: Erector spinae; IMAT; MRI; Muscle fat fraction; Psoas; Thigh.

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Conflict of interest statement

None of the authors has any financial or non-financial interests that are directly or indirectly related to the work submitted for publication. Klaus Engelke is a part time employee of Clario, Inc.

Figures

Fig. 1
Fig. 1
a MRI of the thigh. Left: T1 weighted sequence with segmented fascia lata; center: Dixon fat fraction image; right: separation of IMAT (yellow) and muscle tissue (red). b MRI of paraspinal muscles. Left: T1 weighted sequence with segmented muscles; center: Dixon fat fraction image; right: separation of IMAT (yellow) and muscle tissue (dark)
Fig. 2
Fig. 2
Age-related changes of FL, IMAT and MT volume and MT FF at the thigh. Linear and quadratic fits are shown as solid and dashed lines, respectively
Fig. 3
Fig. 3
a Age-related changes of FL, IMAT and MT volume and MT FF at the psoas muscle. Linear and quadratic fits are shown as solid and dashed lines, respectively. b Age-related changes of FL, IMAT and MT volume and MT FF at the erector spinae muscle. Linear and quadratic fits are shown as solid and dashed lines, respectively
See this image and copyright information in PMC

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References

    1. Cruz-Jentoft AJ, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16–31. doi: 10.1093/ageing/afy169. - DOI - PMC - PubMed
    1. Goodpaster BH, et al. Attenuation of skeletal muscle and strength in the elderly: the health ABC study. J Appl Physiol (1985) 2001;90:2157–2165. doi: 10.1152/jappl.2001.90.6.2157. - DOI - PubMed
    1. Goodpaster BH, et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006;61:1059–1064. doi: 10.1093/gerona/61.10.1059. - DOI - PubMed
    1. Addison O, et al. Intermuscular fat: a review of the consequences and causes. Int J Endocrinol. 2014;2014:309570. doi: 10.1155/2014/309570. - DOI - PMC - PubMed
    1. Buch A, et al. Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age—an overview. Exp Gerontol. 2016;76:25–32. doi: 10.1016/j.exger.2016.01.008. - DOI - PubMed

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