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Review
. 2022 May 13:13:801303.
doi: 10.3389/fendo.2022.801303. eCollection 2022.

SIRT1-SIRT7 in Diabetic Kidney Disease: Biological Functions and Molecular Mechanisms

Wenxiu Qi  1 , Cheng Hu  2 , Daqing Zhao  1 , Xiangyan Li  1
Affiliations
Review

SIRT1-SIRT7 in Diabetic Kidney Disease: Biological Functions and Molecular Mechanisms

Wenxiu Qi et al. Front Endocrinol (Lausanne). .

Abstract

Diabetic kidney disease (DKD) is a severe microvascular complication in patients with diabetes and is one of the main causes of renal failure. The current clinical treatment methods for DKD are not completely effective, and further exploration of the molecular mechanisms underlying the pathology of DKD is necessary to improve and promote the treatment strategy. Sirtuins are class III histone deacetylases, which play an important role in many biological functions, including DNA repair, apoptosis, cell cycle, oxidative stress, mitochondrial function, energy metabolism, lifespan, and aging. In the last decade, research on sirtuins and DKD has gained increasing attention, and it is important to summarize the relationship between DKD and sirtuins to increase the awareness of DKD and improve the cure rates. We have found that miRNAs, lncRNAs, compounds, or drugs that up-regulate the activity and expression of sirtuins play protective roles in renal function. Therefore, in this review, we summarize the biological functions, molecular targets, mechanisms, and signaling pathways of SIRT1-SIRT7 in DKD models. Existing research has shown that sirtuins have the potential as effective targets for the clinical treatment of DKD. This review aims to lay a solid foundation for clinical research and provide a theoretical basis to slow the development of DKD in patients.

Keywords: biological function; diabetes kidney disease; pathological process; signaling pathway; sirtuins.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Biological role of SIRT1–SIRT7 in different DKD cell models.
Figure 2
Figure 2
Basic structure of nephron and glomerulus and different cell models for sirtuins studies.
Figure 3
Figure 3
The targets and signaling pathways of different drugs or compounds regulated by sirtuins were summarized.
See this image and copyright information in PMC

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