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. 2022 May 11:13:880467.
doi: 10.3389/fendo.2022.880467. eCollection 2022.

Sexual Dimorphism in the Association of Serum Retinol-Binding Protein-4 With Long-Term Dynamic Metabolic Profiles in Non-Diabetes

Jiali Xiang  1   2 , Huajie Dai  1   2 , Yanan Hou  1   2 , Qi Wang  1   2 , Tiange Wang  1   2 , Mian Li  1   2 , Zhiyun Zhao  1   2 , Jieli Lu  1   2 , Meng Dai  1   2 , Di Zhang  1   2 , Yu Xu  1   2 , Guang Ning  1   2 , Weiqing Wang  1   2 , Jiqiu Wang  1   2 , Yufang Bi  1   2 , Min Xu  1   2
Affiliations

Sexual Dimorphism in the Association of Serum Retinol-Binding Protein-4 With Long-Term Dynamic Metabolic Profiles in Non-Diabetes

Jiali Xiang et al. Front Endocrinol (Lausanne). .

Abstract

Objectives: We aimed to investigate the association of circulating retinol-binding protein-4 (RBP4) levels with long-term cardiometabolic risk profiles and whether sex disparity mattered.

Methods: We included 784 non-diabetic participants aged 40 years and above from a well-defined community-based cohort at baseline in 2005 and they were invited to attend the on-site follow-up examination for two consecutive times with 3-year intervals in 2008 and 2011, respectively. Serum RBP4 was measured at baseline, and the anthropometry and biochemical measurements were performed at each visit. Generalized estimating equation models were used to assess the association of serum RBP4 levels with the dynamic changes in adiposity and glucolipid profile.

Results: Based on all the baseline and the 3- and 6-year follow-up data, baseline serum RBP4 levels (each 1-unit of log10RBP4) were significantly associated with waist circumference [β=3.12, 95% confidence interval (CI) (0.77, 5.47), P=0.01], fasting, and 2-h post-loading glucose [β=0.26 (0.05, 0.47), P=0.02, and 1.70 (1.29, 2.12), P< 0.0001], serum triglycerides [β=0.75, 95% CI (0.54, 0.96), P< 0.0001], total cholesterol [β=0.47, 95% CI [0.23 0.70], P<0.0001), and marginally with body mass index (β=0.97, 95% CI (0.02, 1.93), P=0.046], in total participants, after adjusting potential confounders. The association of RBP4 with 2-h post-loading glucose was stronger in women than that in men [β=1.99, 95% CI (1.49, 2.50) vs. 0.61 (-0.14, 1.36), P for interaction=0.001]. The analysis of change in Z-score of cardiometabolic profiles corresponding to each 1-unit increment in log10RBP4 showed consistent results.

Conclusions: Higher RBP4 levels are associated with longitudinal increase in adiposity and deteriorated glucolipid profile defined by repeated measurements. The associations differ in sex regarding to the 2-h post-loading glucose.

Keywords: adiposity; dynamic change; long-term follow-up; metabolic profile; retinol-binding protein-4.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of study population.
Figure 2
Figure 2
Age adjusted means of metabolic traits at baseline, 3-year follow-up and 6-year follow-up. P values were calculated from analysis of covariance. *P value significant compared with baseline, #P value significant compared with 3-year follow-up.
See this image and copyright information in PMC

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