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Editorial
. 2022 Jul 1;323(1):F1-F3.
doi: 10.1152/ajprenal.00130.2022. Epub 2022 May 30.

The Janus view: dual roles for hypoxia-inducible factor in renal repair after acute kidney injury

Bohan Chen  1 , Andrew S Brem  2 , Rujun Gong  1
Affiliations
Editorial

The Janus view: dual roles for hypoxia-inducible factor in renal repair after acute kidney injury

Bohan Chen et al. Am J Physiol Renal Physiol. .
No abstract available

Keywords: acute kidney injury; hypoxia-inducible factor.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

Figure 1.
Figure 1.
Divergent roles of hypoxia-inducible factor (HIF)/β-catenin signaling in adaptive renal repair may determine distinct renal outcomes after acute kidney injury (AKI). Adaptive repair after mild AKI is associated with rapid and transient activation of HIF, whereas maladaptive repair following severe AKI is associated with a delayed and sustained HIF response. Activation of HIF in renal tubules, peritubular capillary endothelial cells, or renal interstitial fibroblasts could trigger the β-catenin signaling and, depending on the timing of the HIF response, could subsequently induce either the expression of c-Myc, cyclin D1, and VEGFα, which are proreparative factors involved in the regeneration of renal tubules and peritubular capillaries and post-AKI repair or the expression of Snail1, fibronectin, and collagen, which are profibrotic mediators involved in renal fibrosis and the transition to chronic kidney disease. PAI-1, plasminogen activator inhibitor-1.
See this image and copyright information in PMC

Comment on

References

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