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Review
. 2022 Jun;36(2):379-395.
doi: 10.1016/j.idc.2022.02.004. Epub 2022 Feb 15.

Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Aluko A Hope  1 , Teresa H Evering  2
Affiliations
Review

Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Aluko A Hope et al. Infect Dis Clin North Am. 2022 Jun.

Abstract

Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or long coronavirus disease (COVID) is an emerging syndrome characterized by multiple persisting or newly emergent symptoms following the acute phase of SARS-CoV-2 infection. For affected patients, these prolonged symptoms can have a relapsing and remitting course and may be associated with disability and frequent health care utilization. Although many symptom-driven treatments are available, management remains challenging and often requires a multidisciplinary approach. This article summarizes the emerging consensus on definitions, epidemiology, and pathophysiology of long COVID and discusses what is understood about prevention, evaluation, and treatment of this syndrome.

Keywords: COVID-19; Long COVID; Long-haul COVID; Postacute COVID-19; Postacute sequelae of SARS-CoV-2 infection (PASC); SARS-CoV-2.

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Conflict of interest statement

Disclosure T.H. Evering, author, is a consultant for Tonix Pharmaceuticals. Aluko A. Hope is funded by the NIH (K01 HL 140279). I am waiting to hear from Teresa regarding her NIH funding sources.

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