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. 2022 Jul 1;34(3):288-295.
doi: 10.1097/PEP.0000000000000913. Epub 2022 May 30.

Characterizing Pain Among Adolescents and Young Adults With Arthrogryposis Multiplex Congenita

Jaclyn Megan Sions  1 , Maureen Donohoe, Emma Haldane Beisheim-Ryan, Ryan Todd Pohlig, Tracy Michele Shank, Louise Reid Nichols
Affiliations

Characterizing Pain Among Adolescents and Young Adults With Arthrogryposis Multiplex Congenita

Jaclyn Megan Sions et al. Pediatr Phys Ther. .

Abstract

Purpose: Primary study objectives were to ( a ) characterize pain and explore differences between adolescents and adults with arthrogryposis multiplex congenita (AMC) and ( b ) evaluate associations between pain-related outcomes and mobility.

Methods: People who can walk and with AMC completed pain-related questionnaires.

Results: Sixty-three participants (28 adolescents and 35 young adults) were recruited. Pain was reported in the past week by 81% of participants; intensity ratings were similar between age groups. Per the McGill Pain Questionnaire, pain severity was significantly lower among adolescents. Adults had a greater number of painful regions compared with adolescents. Greater 7-day average pain intensity, McGill Pain Questionnaire scores, and number of painful regions were associated with reduced functional mobility.

Conclusions: As most adolescents and young adults with AMC have at least mild pain, and pain is associated with mobility, future longitudinal investigations of pain and its functional consequences are warranted.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
Pain Body Diagrams
See this image and copyright information in PMC

Comment in

References

    1. Cachecho S, Elfassy C, Hamdy R, Rosenbaum P, Dahan-Oliel N. Arthrogryposis multiplex congenita definition: Update using an international consensus-based approach. Am J Med Genet C Semin Med Genet. 2019;181(3):280–7. doi:10.1002/ajmg.c.31739 - DOI - PubMed
    1. Lowry RB, Sibbald B, Bedard T, Hall JG. Prevalence of multiple congenital contractures including arthrogryposis multiplex congenita in Alberta, Canada, and a strategy for classification and coding. Birth Defects Res A Clin Mol Teratol. 2010;88(12):1057–61. doi:10.1002/bdra.20738 - DOI - PubMed
    1. Dubousset J, Guillaumat M. Long-term outcome for patients with arthrogryposis multiplex congenita. J Child Orthop. 2015;9(6):449–58. doi:10.1007/s11832-015-0692-6 - DOI - PMC - PubMed
    1. McMillin MJ, Beck AE, Chong JX, et al. Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5. Am J Hum Genet. 2014;94(5):734–44. doi:10.1016/j.ajhg.2014.03.015 - DOI - PMC - PubMed
    1. Gagnon M, Caporuscio K, Veilleux LN, Hamdy R, Dahan-Oliel N. Muscle and joint function in children living with arthrogryposis multiplex congenita: A scoping review. Am J Med Genet C Semin Med Genet. 2019;181(3):410–26. doi:10.1002/ajmg.c.31726 - DOI - PubMed

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