Metabolic Dysregulation and Sperm Motility in Male Infertility

doi:10.1007/978-3-030-89340-8_12

Review

. 2022:1358:257-273.

doi: 10.1007/978-3-030-89340-8_12.

Metabolic Dysregulation and Sperm Motility in Male Infertility

Affiliations

¹ Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida, India.
² Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo, Finland.
³ Department of Life Science and Bioinformatics, Assam University, Silchar, India.
⁴ Department of Chemistry, Indian Institute of Technology Jammu, Jammu, Jammu & Kashmir, India.
⁵ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, India.
⁶ Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, India.
⁷ Mahavir Cancer Sansthan and Research Centre, Patna, Bihar, India.
⁸ Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College, University of Delhi, New Delhi, India.
⁹ Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida, India. dhruvbhu@gmail.com.

PMID: 35641874
DOI: 10.1007/978-3-030-89340-8_12

Review

Metabolic Dysregulation and Sperm Motility in Male Infertility

Sujata Maurya et al. Adv Exp Med Biol. 2022.

. 2022:1358:257-273.

doi: 10.1007/978-3-030-89340-8_12.

Authors

Affiliations

¹ Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida, India.
² Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo, Finland.
³ Department of Life Science and Bioinformatics, Assam University, Silchar, India.
⁴ Department of Chemistry, Indian Institute of Technology Jammu, Jammu, Jammu & Kashmir, India.
⁵ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, India.
⁶ Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, India.
⁷ Mahavir Cancer Sansthan and Research Centre, Patna, Bihar, India.
⁸ Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College, University of Delhi, New Delhi, India.
⁹ Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida, India. dhruvbhu@gmail.com.

PMID: 35641874
DOI: 10.1007/978-3-030-89340-8_12

Abstract

Nowadays, about 14% of couples have difficulty in conceiving, and half of the cases are attributed to men. Asthenozoospermia or poor sperm motility is considered as the cause of infertility in males which is most common. Even though energy metabolism is considered the main reason for the etiology of asthenospermia, few attempts are made to determine the pathway of its metabolic potential. Recognition of cellular as well as molecular pathways that lead to reduced sperm motility may lead to the implementation of new therapeutic strategies to eliminate low sperm motility in people with asthenozoospermia. This review article discusses the key causes of decreased sperm motility and some of the muted genes and metabolic causes of the same.

Keywords: ATP production; Asthenozoospermia; Autophagy; Curcumin; Glycolysis; Male infertility; OXPHOS; ROS; cAMP/PRKA pathway.

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References

1. Agarwal A, Virk G, Ong C, du Plessis SS. Effect of oxidative stress on male reproduction. World J Men’s Health. 2014;32(1):1–17. https://doi.org/10.5534/wjmh.2014.32.1.1 . - DOI
1. Aitken RJ, Koppers AJ. Apoptosis and DNA damage in human spermatozoa. Asian J Androl. 2011;13(1):36–42. https://doi.org/10.1038/aja.2010.68 . - DOI - PubMed
1. Alahmar AT. Role of oxidative stress in male infertility: an updated review. J Hum Reprod Sci. 2019;12(1):4–18. https://doi.org/10.4103/jhrs.JHRS_150_18 . - DOI - PubMed - PMC
1. Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review. J Tradit Complement Med. 2016;7(2):205–33. https://doi.org/10.1016/j.jtcme.2016.05.005 . - DOI - PubMed - PMC
1. Asghari A, Marashi SA, Ansari-Pour N. A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia. Syst Biol Reprod Med. 2017;63(2):100–12. https://doi.org/10.1080/19396368.2016.1263367 . - DOI - PubMed

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[1] Agarwal A, Virk G, Ong C, du Plessis SS. Effect of oxidative stress on male reproduction. World J Men’s Health. 2014;32(1):1–17. https://doi.org/10.5534/wjmh.2014.32.1.1 . - DOI

[2] Agarwal A, Virk G, Ong C, du Plessis SS. Effect of oxidative stress on male reproduction. World J Men’s Health. 2014;32(1):1–17. https://doi.org/10.5534/wjmh.2014.32.1.1 . - DOI

[3] Aitken RJ, Koppers AJ. Apoptosis and DNA damage in human spermatozoa. Asian J Androl. 2011;13(1):36–42. https://doi.org/10.1038/aja.2010.68 . - DOI - PubMed

[4] Aitken RJ, Koppers AJ. Apoptosis and DNA damage in human spermatozoa. Asian J Androl. 2011;13(1):36–42. https://doi.org/10.1038/aja.2010.68 . - DOI - PubMed

[5] Alahmar AT. Role of oxidative stress in male infertility: an updated review. J Hum Reprod Sci. 2019;12(1):4–18. https://doi.org/10.4103/jhrs.JHRS_150_18 . - DOI - PubMed - PMC

[6] Alahmar AT. Role of oxidative stress in male infertility: an updated review. J Hum Reprod Sci. 2019;12(1):4–18. https://doi.org/10.4103/jhrs.JHRS_150_18 . - DOI - PubMed - PMC

[7] Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review. J Tradit Complement Med. 2016;7(2):205–33. https://doi.org/10.1016/j.jtcme.2016.05.005 . - DOI - PubMed - PMC

[8] Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review. J Tradit Complement Med. 2016;7(2):205–33. https://doi.org/10.1016/j.jtcme.2016.05.005 . - DOI - PubMed - PMC

[9] Asghari A, Marashi SA, Ansari-Pour N. A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia. Syst Biol Reprod Med. 2017;63(2):100–12. https://doi.org/10.1080/19396368.2016.1263367 . - DOI - PubMed

[10] Asghari A, Marashi SA, Ansari-Pour N. A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia. Syst Biol Reprod Med. 2017;63(2):100–12. https://doi.org/10.1080/19396368.2016.1263367 . - DOI - PubMed

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Metabolic Dysregulation and Sperm Motility in Male Infertility

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Metabolic Dysregulation and Sperm Motility in Male Infertility

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