Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jun;26(6):537-546.
doi: 10.1080/14728222.2022.2082937. Epub 2022 Jun 2.

Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson's disease

Jillian H Kluss  1   2 , Patrick A Lewis  1   3   4 , Elisa Greggio  5   6
Affiliations
Free article
Review

Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson's disease

Jillian H Kluss et al. Expert Opin Ther Targets. 2022 Jun.
Free article

Abstract

Areas covered: In this review, we will provide an update on the current status of drugs and other technologies that have emerged in recent years and provide an overview of their efficacy in ameliorating LRRK2 kinase activity and overall safety in animal models and humans.

Expert opinion: The growth of both target discovery and innovative drug design has sparked a lot of excitement for the future of how we treat Parkinson's disease. Given the immense focus on LRRK2 as a therapeutic target, it is expected within the next decade to determine its therapeutic properties, or lack thereof, for PD.

Keywords: LRRK2; Leucine-rich repeat kinase 2; Parkinson’s disease; kinase inhibition.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources