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Comment
. 2022 Nov;77(5):1458-1459.
doi: 10.1016/j.jhep.2022.05.015. Epub 2022 May 25.

Lack of hepatic autophagy promotes severity of liver injury but not steatosis

Wen-Xing Ding  1 , Hong-Min Ni  2 , Satoshi Waguri  3 , Masaaki Komatsu  4
Affiliations
Comment

Lack of hepatic autophagy promotes severity of liver injury but not steatosis

Wen-Xing Ding et al. J Hepatol. 2022 Nov.
No abstract available

Keywords: ATG5; ATG7; Inflammation; liver injury; liver tumorigenesis.

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Conflict of interest statement

Conflict of interest The authors disclose no conflicts. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1.
Fig. 1.. L-ATG5 and L-ATG7 KO mice have impaired fasting-induced hepatic LD accumulation.
L-ATG5 and L-ATG7 KO mice were either fed with a chow diet or fasted overnight (L-ATG5 KO) or 24 hrs (L-ATG7 KO). Liver tissues were fixed and subjected to Oil Red O staining (A, B) or EM analysis (C, D). Representative images are shown. Bar: 1 μm. EM, electron microscope; KO, knockout; LD, lipid droplet.
See this image and copyright information in PMC

Comment in

Comment on

  • Rare ATG7 genetic variants predispose patients to severe fatty liver disease.
    Baselli GA, Jamialahmadi O, Pelusi S, Ciociola E, Malvestiti F, Saracino M, Santoro L, Cherubini A, Dongiovanni P, Maggioni M, Bianco C, Tavaglione F, Cespiati A, Mancina RM, D'Ambrosio R, Vaira V, Petta S, Miele L, Vespasiani-Gentilucci U, Federico A, Pihlajamaki J, Bugianesi E, Fracanzani AL, Reeves HL, Soardo G, Prati D, Romeo S, Valenti LV; EPIDEMIC Study Investigators. Baselli GA, et al. J Hepatol. 2022 Sep;77(3):596-606. doi: 10.1016/j.jhep.2022.03.031. Epub 2022 Apr 9. J Hepatol. 2022. PMID: 35405176

References

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