Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Jul;39(4):619-621.
doi: 10.1111/pde.15032. Epub 2022 May 29.

A case of wild-type rubella-associated cutaneous granuloma in ataxia telangiectasia

Rachel Browne  1 , Lucy Cliffe  2 , Winne Ip  3 , Kevin Brown  4 , Elizabeth McDermott  2
Affiliations
Case Reports

A case of wild-type rubella-associated cutaneous granuloma in ataxia telangiectasia

Rachel Browne et al. Pediatr Dermatol. 2022 Jul.

Abstract

Granulomatous skin disease is known to be associated with various primary immunodeficiencies, including ataxia telangiectasia (AT). Recent reports of persistence of live vaccine strain rubella within such cutaneous granulomas have raised concern regarding the safety of vaccination. Here we report a case of cutaneous granuloma in association with AT, demonstrating wild type, rather than vaccine strain rubella. This supports the persistence of rubella as a causative mechanism, but suggests it is not vaccine strain-specific, and thus may impact the decision of those considering not vaccinating this subset of children.

Keywords: ataxia telangiectasia; cutaneous granuloma; granulomatous skin disease; immunodeficiency; rubella.

PubMed Disclaimer

References

REFERENCES

    1. Leclerc-Mercier S, Moshous D, Neven B, et al. Cutaneous granulomas with primary immunodeficiency in children: a report of 17 new patients and a review of the literature. J Eur Acad Dermatol Venereol. 2019;33(7):1412-1420.
    1. Buchbinder D, Hauck F, Albert MH, et al. Rubella virus-associated cutaneous granulomatous disease: a unique complication in immune-deficient patients, not limited to DNA repair disorders. J Clinical Immunol. 2019;39(1):81-89.
    1. Chiam LY, Verhagen MM, Haraldsson A, et al. Cutaneous granulomas in ataxia telangiectasia and other primary immunodeficiencies: reflection of inappropriate immune regulation? Dermatology. 2011;223(1):13-19.
    1. Jin L, Thomas B. Application of molecular and serological assays to case based investigations of rubella and congenital rubella syndrome. J Med Virol. 2007;79(7):1017-1024.
    1. Bodemer C, Sauvage V, Mahlaoui N, et al. Live rubella virus vaccine long-term persistence as an antigenic trigger of cutaneous granulomas in patients with primary immunodeficiency. Clin Microbiol Infect. 2014;20(10):O656-O663.

Publication types

LinkOut - more resources