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. 2022 May 12:16:888198.
doi: 10.3389/fnins.2022.888198. eCollection 2022.

Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage

Zi-Jie Wang  1 , Rui Zhao  2 , Xiao Hu  1 , Wen-Song Yang  1   3 , Lan Deng  1 , Xin-Ni Lv  1 , Zuo-Qiao Li  1 , Jing Cheng  1 , Ming-Jun Pu  1 , Zhou-Ping Tang  4 , Guo-Feng Wu  5 , Li-Bo Zhao  2 , Peng Xie  1   3 , Qi Li  1   3   6
Affiliations

Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage

Zi-Jie Wang et al. Front Neurosci. .

Abstract

Objective: To investigate the association between cerebral small vessel disease (SVD) and hematoma volume in primary intracerebral hemorrhage (ICH).

Methods: Patients from a prospective ICH cohort were enrolled. Admission and follow-up CT scan within 72 h after onset were reviewed to calculate the final hematoma volume. We evaluated cortical superficial siderosis and the global SVD score, including white matter hyperintensities, lacunes, enlarged perivascular space, and cerebral microbleeds on MRI. We conducted the multivariate logistic regression analyses to explore the association between SVD markers and small ICH, as well as hematoma volume. Hematoma location was stratified into lobar and non-lobar for subgroup analysis.

Results: A total of 187 patients with primary ICH (mean age 62.4 ± 13.4 years, 67.9% male) were enrolled. 94 (50.2%) patients had small ICH. The multivariate logistic regression analysis showed an association between global SVD score and small ICH [adjusted odds ratio (aOR) 1.27, 95% CI 1.03-1.57, p = 0.027] and a trend of higher global SVD score towards non-lobar small ICH (aOR 1.23, 95% CI 0.95-1.58, p = 0.122). In the multivariate linear regression analysis, global SVD score was inversely related to hematoma volume of all ICH (β = -0.084, 95% CI -0.142 to -0.025, p = 0.005) and non-lobar ICH (β = -0.112, 95% CI -0.186 to -0.037, p = 0.004). Lacune (β = -0.245, 95% CI -0.487 to -0.004, p = 0.046) was associated with lower non-lobar ICH volume.

Conclusion: Global SVD score is associated with small ICH and inversely correlated with hematoma volume. This finding predominantly exists in non-lobar ICH.

Keywords: cerebral small vessel disease; computed tomography; intracerebral hemorrhage; magnetic resonance imaging; neuroimaging; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Study flowchart.
FIGURE 2
FIGURE 2
Distribution of small vessel disease (SVD) severity in patients with small and non-small intracerebral hemorrhage (ICH).
FIGURE 3
FIGURE 3
Simple linear regression model of log-transformed hematoma volume and global SVD score in lobar and non-lobar ICH. The dependent variable was base-10 logarithm of hematoma volume. Log of hematoma volume in non-lobar ICH = -0.133 × Global SVD score + 0.993, p < 0.001. Log of hematoma volume in lobar ICH = -0.013 × Global SVD score + 1.226, p = 0.765.
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References

    1. Akoudad S., Portegies M. L. P., Koudstaal P. J., Hofman A., Van Der Lugt A., Ikram M. A., et al. (2015). Cerebral Microbleeds Are Associated with an Increased Risk of Stroke: The Rotterdam Study. Circulation 132 509–516. 10.1161/CIRCULATIONAHA.115.016261 - DOI - PubMed
    1. Boulouis G., Van Etten E. S., Charidimou A., Auriel E., Morotti A., Pasi M., et al. (2016). Association of key magnetic resonance imaging markers of cerebral small vessel disease with hematoma volume and expansion in patients with lobar and deep intracerebral hemorrhage. JAMA Neurol. 73 1440–1447. 10.1001/jamaneurol.2016.2619 - DOI - PMC - PubMed
    1. Charidimou A., Boulouis G., Greenberg S. M., Viswanathan A. (2019). Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: A meta-analysis. Neurology 93 e2192–e2202. 10.1212/WNL.0000000000008590 - DOI - PMC - PubMed
    1. Charidimou A., Gang Q., Werring D. J. (2012). Sporadic cerebral amyloid angiopathy revisited: Recent insights into pathophysiology and clinical spectrum. J. Neurol. Neurosurg. Psychiatry 83 124–137. 10.1136/jnnp-2011-301308 - DOI - PubMed
    1. Charidimou A., Imaizumi T., Moulin S., Biffi A., Samarasekera N., Yakushiji Y., et al. (2017a). Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: A meta-analysis. Neurology 89 820–829. 10.1212/WNL.0000000000004259 - DOI - PMC - PubMed

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