Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 1;12(2):e2022094.
doi: 10.5826/dpc.1202a94. eCollection 2022 May.

Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases

Michela Lai  1   2 , Simonetta Piana  3 , Giovanni Pellacani  4 , Caterina Longo  1   2 , Riccardo Pampena  1   2
Affiliations

Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases

Michela Lai et al. Dermatol Pract Concept. .

Abstract

Introduction: Nevus-associated melanoma (NAM) accounts for almost one third of all cutaneous melanomas; it is often associated with younger age, trunk location and lower Breslow's thickness compared to de novo melanoma (DNM).

Objectives: To define the prevalence of NAM in a tertiary referral Center in Italy and to analyze its distribution according to demographics, clinical and histopathological variables.

Methods: Data were retrospectively retrieved from the archive of the Pathology Unit from June 2011 to August 2020. NAMs were compared with DNMs according to demographic, clinical and histopathological variables.

Results: A total of 2806 consecutive cases of melanoma were excised in 2537 patients. Of these, 431 (15.4%) were NAM. NAM patients were significantly younger than DNM patients (55.1±14.1 vs. 62.0±15.0 years, p<0.001); they were predominantly located on the trunk (64.0% vs. 47.9% of DNMs). Melanoma located on the head and neck, trunk and upper limbs respectively had 2.3 (95%CI:1.2-4.5, p:0.014), 3.2 (95%CI:2.1-5.1, p<0.001) and 3.5 (95%CI:2.0-6.1, p<0.001) more odds to be NAM than those on the lower limbs.

Conclusions: Our results confirm the association of NAM with younger age and trunk location. We also demonstrated that body site differences of NAM distribution are enhanced before the sixth decade of life.

Keywords: de novo melanoma; melanoma; nevus-associated melanoma.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Ratio of nevus-associated versus de-novo melanoma according to body site and age-groups. DNM = de novo melanoma; NAM = nevus-associated melanoma.
See this image and copyright information in PMC

References

    1. Pampena R, Kyrgidis A, Lallas A, Moscarella E, Argenziano G, Longo C. A meta-analysis of nevus-associated melanoma: Prevalence and practical implications. J Am Acad Dermatol. 2017;77(5) doi: 10.1016/j.jaad.2017.06.149. - DOI - PubMed
    1. Pandeya N, Kvaskoff M, Olsen CM, et al. Factors Related to Nevus-Associated Cutaneous Melanoma: A Case-Case Study. J Invest Dermatol. 2018;138(8) doi: 10.1016/j.jid.2017.12.036. - DOI - PubMed
    1. Longo C, Rito C, Beretti F, et al. De novo melanoma and melanoma arising from pre-existing nevus: In vivo morphologic differences as evaluated by confocal microscopy. J Am Acad Dermatol. 2011;65(3) doi: 10.1016/j.jaad.2010.10.035. - DOI - PubMed
    1. Haenssle HA, Mograby N, Ngassa A, et al. Association of Patient Risk Factors and Frequency of Nevus-Associated Cutaneous Melanomas. JAMA Dermatol. 2016;152(3) doi: 10.1001/jamadermatol.2015.3775. - DOI - PubMed
    1. Pampena R, Pellacani G, Longo C. Nevus-Associated Melanoma: Patient Phenotype and Potential Biological Implications. J Invest Dermatol. 2018;138(8) doi: 10.1016/j.jid.2018.01.025. - DOI - PubMed

LinkOut - more resources