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. 2022 Apr 1;12(2):e2022070.
doi: 10.5826/dpc.1202a70. eCollection 2022 May.

Birth of a Melanoma

Sofia Bogiatzi  1 , Alessandra Pagnoni  1 , Daniel Hohl  1 , Olivier Gaide  1
Affiliations

Birth of a Melanoma

Sofia Bogiatzi et al. Dermatol Pract Concept. .
No abstract available

Keywords: dermatopathology; dermoscopy; melanoma; total body photography.

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Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Total Body Photography exam: a new lesion is identified during time-lapse comparison of photos. (A) Total-body-photography at visit 1. (B) Total-body-photography at visit 2, one year later revealing the presence of a new melanocytic lesion. Inset: high power of the new lesion showing a darker pigmentation than the rest of the nevi. (C) Digital dermoscopy of the new lesion showing an atypical melanocytic network with irregular streaks and pseudopods in an asymmetrical starburst pattern dominating one extremity of the lesion.
Figure 2
Figure 2
Histopathology correlate revealing features of melanoma in situ. (A–D) 10x magnification sections in different levels of the lesion depicting the asymmetrical melanocytic growth with junctional nests of various sizes, distributed unevenly. (E) 40x magnification of the B section showing the lentiginous spread in contact with a peripheral nest, corresponding to the pseudopods seen in dermoscopy. The melanocytes exhibit large nuclei compared to the neighboring keratinocytes with abundant cytoplasm, and heavy pigmentation in some of the cells. No pagetoid scatter was observed in the periphery of the lesion, compatible with an acral lentiginous subtype melanoma. (F) 40x magnification of a central nest with a mitotic figure (red asterisk). (G) 40x magnification of the D section showing interconnected nests in the center of the lesion with scattered melanocytes in the suprabasal layers of the epidermis (green asterisks), compatible with pagetoid ascension.
See this image and copyright information in PMC

References

    1. Drugge ED, Volpicelli ER, Sarac RM, Strang SR, Elston DM, Drugge RJ. Micromelanomas identified with time-lapse total body photography and dermoscopy. J Am Acad Dermatol. 2018;78(1):182–183. doi: 10.1016/j.jaad.2017.07.049. - DOI - PubMed
    1. Hornung A, Steeb T, Wessely A, et al. The Value of Total Body Photography for the Early Detection of Melanoma: A Systematic Review. Int J Environ Res Public Health. 2021;18(4):1726. doi: 10.3390/ijerph18041726. - DOI - PMC - PubMed

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