Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 13:12:913254.
doi: 10.3389/fonc.2022.913254. eCollection 2022.

Prognostic Factors and Treatment Strategies for Elderly Patients with Malignant Meningioma: A SEER Population-Based Study

Songshan Feng  1   2   3   4 , Jing Li  5 , Fan Fan  1 , Zeyu Wang  1 , Qian Zhang  6 , Hao Zhang  1 , Ziyu Dai  1 , Xun Zhang  1 , Peng Luo  7 , Zaoqu Liu  8 , Jian Zhang  7 , Zhuoyi Liu  6 , Quan Cheng  1   2   9
Affiliations

Prognostic Factors and Treatment Strategies for Elderly Patients with Malignant Meningioma: A SEER Population-Based Study

Songshan Feng et al. Front Oncol. .

Abstract

Objective: Malignant meningioma (MM) is a relatively rare disease with poor survival. Few studies had focused on MM in the elderly population. This study aims to explore the prognostic factors and optimal therapeutic strategy in elderly patients with MM.

Methods: We took advantage of the Surveillance, Epidemiology, and End Results (SEER) database to include 275 adult patients with histologically confirmed MM between 2011 and 2018. The Kaplan-Meier curves were plotted by different covariates to reveal the survival probability. Univariate and multivariable Cox proportional hazard regression analyses were applied to identify prognostic factors for cancer-specific survival (CSS).

Results: The multivariable analysis in the elderly group revealed that when compared with patients receiving gross total resection (GTR), patients receiving biopsy had significantly worse CSS (HR = 3.72; 95% CI: 1.35-10.21; P = 0.011), whereas patients receiving subtotal resection (STR) had nearly the same CSS (HR = 0.83; 95% CI: 0.37-1.86; P = 0.653). Meanwhile, postoperative radiotherapy (PORT) showed no significant association with CSS in the elderly patient group (HR = 0.94; 95% CI: 0.42-2.12; P = 0.888).

Conclusion: Surgical resection is recommended for elderly patients with MM in the absence of surgical contraindications, but GTR does not present survival benefit in the elderly patients compared with STR. Additional large-scale clinical studies are needed to explore the survival benefit of PORT applied in patients with MM.

Keywords: SEER; elderly patient; malignant meningioma; patient prognosis; treatment strategy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of patient selection criteria with de novo MM between 2011 and 2018.
Figure 2
Figure 2
The Kaplan–Meier curves by (A) age group, (B) tumor size, (C) EOR, and (D) PORT in the entire cohort.
Figure 3
Figure 3
The Kaplan–Meier curves by EOR and PORT in different age groups. (A) EOR in group <65 years. (B) EOR in group ≥65 years. (C) PORT in group <65 years. (D) PORT in group ≥65 years.
See this image and copyright information in PMC

References

    1. Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017. Neuro Oncol (2020) 22(12 Suppl 2):iv1–96. doi: 10.1093/neuonc/noaa200 - DOI - PMC - PubMed
    1. Wiemels J, Wrensch M, Claus EB. Epidemiology and Etiology of Meningioma. J Neurooncol (2010) 99:307–14. doi: 10.1007/s11060-010-0386-3 - DOI - PMC - PubMed
    1. Meehan TP, Fine MJ, Krumholz HM, Scinto JD, Galusha DH, Mockalis JT, et al. . Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia. JAMA (1997) 278:2080–4. doi: 10.1001/jama.1997.03550230056037 - DOI - PubMed
    1. Orton A, Frandsen J, Jensen R, Shrieve DC, Suneja G. Anaplastic Meningioma: An Analysis of the National Cancer Database From 2004 to 2012. J Neurosurg (2018) 128:1684–9. doi: 10.3171/2017.2.JNS162282 - DOI - PubMed
    1. Champeaux C, Jecko V, Houston D, Thorne L, Dunn L, Fersht N, et al. . Malignant Meningioma: An International Multicentre Retrospective Study. Neurosurgery (2019) 85:E461–9. doi: 10.1093/neuros/nyy610 - DOI - PubMed

LinkOut - more resources