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Case Reports
. 2022 Apr 26;63(1):E139-E141.
doi: 10.15167/2421-4248/jpmh2022.63.1.2261. eCollection 2022 Mar.

Clinical characterization and whole genome sequence-based typing of two cases of endophthalmitis due to Listeria monocytogenes

Maria Gori  1 , Silvia Bianchi  1 , Giulia Ciceri  1 , Alessia Lai  2 , Marco Tonelli  3 , Nicola Clementi  3 , Massimo Clementi  3 , Nicasio Mancini  3 , Clara Fappani  1 , Gianguglielmo Zehender  2   4 , Antonella Amendola  1   4 , Mirella Pontello  4 , Elisabetta Tanzi  1   4
Affiliations
Case Reports

Clinical characterization and whole genome sequence-based typing of two cases of endophthalmitis due to Listeria monocytogenes

Maria Gori et al. J Prev Med Hyg. .

Abstract

Endophthalmitis due to Listeria monocytogenes is a rare form of listeriosis. Here, we report two cases that occurred in patients with different medical history, a 46-years-old woman with no comorbidities and an elderly man with several comorbidities. There was no history of trauma or surgery in either patient suggesting an endogenous origin. Despite antibiotic treatment, both patients showed poor visual acuity outcomes. Subtyping clinical isolates using whole genome sequencing could allow to characterise Listeria monocytogenes strains involved in rare clinical manifestation, such as in unusual anatomical sites, even in immunocompetent patients.

Keywords: Endophthalmitis; Listeriosis; Surveillance; Virulence; Whole-genome sequencing.

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Conflict of interest statement

Conflict of interest statement The authors declare no conflict of interest.

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