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Review
. 2022 Aug;71(7-8):759-770.
doi: 10.1007/s00011-022-01587-x. Epub 2022 Jun 1.

The purinergic signalling and inflammation in the pathogenesis and progression of diabetes: key factors and therapeutic targets

André Campos de Lima  1 , Lucas Macedo Chaves  2 , Samantha Nuncio Prestes  2 , Aline Mânica  3 , Andreia Machado Cardoso  4
Affiliations
Review

The purinergic signalling and inflammation in the pathogenesis and progression of diabetes: key factors and therapeutic targets

André Campos de Lima et al. Inflamm Res. 2022 Aug.

Abstract

Type 2 diabetes mellitus (T2DM) is an important chronic disease around the world, and according to the World Health Organization, it is the 9th principal cause of global death. This pathology is characterized by high levels of circulating glucose as a result of insulin resistance, and it is well stated that inflammation related to obesity is directly associated with the development of the disease. The purinergic signalling is involved in both pancreatic destruction, which impairs insulin secretion, and the cytokine production that favors insulin resistance in T2DM. In this review, the purinergic signalling aspects will be discussed, showing the impact of the enzymes, nucleotides, nucleosides, and receptors of this system and the cytokines that result in inflammation, in the development and progression of T2DM, besides, pointing the purinergic receptors as a possible therapeutic approach.

Keywords: Immune system; Inflammation; Purinergic signalling; T2DM.

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