Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review

doi:10.1007/s00415-022-11186-9

. 2022 Sep;269(9):4635-4645.

doi: 10.1007/s00415-022-11186-9. Epub 2022 Jun 1.

Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review

Emma Clark¹, Saurab Faruque², Cedric Mutebi³, Newton V Nagirimadugu⁴, Alyssa Kim⁵, Malavika Mahendran⁶, Elaine Sullo⁷, Rajendra Morey⁸, Robert W Turner 2nd^{9

10}

Affiliations

¹ University of California, Berkeley, USA.
² School of Medicine, University of Pittsburgh, Pittsburgh, USA.
³ School of Medicine, Wayne State University, Detroit, USA.
⁴ School of Medicine and Health Sciences, The George Washington University, Washington, USA.
⁵ School of Public Health, Yale University, New Haven, USA.
⁶ The George Washington University, Washington, USA.
⁷ Lee Health, Fort Myers, USA.
⁸ Department of Psychiatry, Duke University, Durham, USA.
⁹ Department of Clinical Research and Leadership, School of Medicine and Health Sciences, The George Washington University, Washington, USA. rwturner124@gwu.edu.
¹⁰ Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. rwturner124@gwu.edu.

PMID: 35648232
DOI: 10.1007/s00415-022-11186-9

Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review

Emma Clark et al. J Neurol. 2022 Sep.

. 2022 Sep;269(9):4635-4645.

doi: 10.1007/s00415-022-11186-9. Epub 2022 Jun 1.

Authors

Emma Clark¹, Saurab Faruque², Cedric Mutebi³, Newton V Nagirimadugu⁴, Alyssa Kim⁵, Malavika Mahendran⁶, Elaine Sullo⁷, Rajendra Morey⁸, Robert W Turner 2nd^{9

10}

Affiliations

¹ University of California, Berkeley, USA.
² School of Medicine, University of Pittsburgh, Pittsburgh, USA.
³ School of Medicine, Wayne State University, Detroit, USA.
⁴ School of Medicine and Health Sciences, The George Washington University, Washington, USA.
⁵ School of Public Health, Yale University, New Haven, USA.
⁶ The George Washington University, Washington, USA.
⁷ Lee Health, Fort Myers, USA.
⁸ Department of Psychiatry, Duke University, Durham, USA.
⁹ Department of Clinical Research and Leadership, School of Medicine and Health Sciences, The George Washington University, Washington, USA. rwturner124@gwu.edu.
¹⁰ Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. rwturner124@gwu.edu.

PMID: 35648232
DOI: 10.1007/s00415-022-11186-9

Abstract

The objective of this systematic review is to synthesize the relevant literature published after 2016 to ascertain the current landscape of science that relates mild traumatic brain injury (mTBI) to the onset of Alzheimer's disease and related dementias (ADRD) and identify areas of need for future research. We conducted database searches and retrieved articles that were published after 2016 that utilized cognitive assessments to understand the relationship between mTBI and ADRD. We identified eight relevant articles in the review process, four of which presented a significant relationship between mTBI and disease or cognitive impairment outcomes. The studies included in this systematic review underscore the need for future research investigating a possible causal relationship between mTBI and ADRDs given the high prevalence of mTBI among brain injury patients and the lack of literature specifically addressing this issue. Future research should standardize the definitions of mTBI, AD, and ADRDs to create reliable and reproducible results that more comprehensively capture the nuances of this relationship.

Keywords: Alzheimer’s disease; Concussion; Dementia; Traumatic brain injury; mTBI.

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References

1. Matthews KA, Xu W, Gaglioti AH et al (2019) Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years. Alzheimers Dement 15:17–24. https://doi.org/10.1016/j.jalz.2018.06.3063 - DOI - PubMed
1. Bazarian JJ, Cernak I, Noble-Haeusslein L et al (2009) Long-term neurologic outcomes after traumatic brain injury. J Head Trauma Rehabil 24:439–451. https://doi.org/10.1097/HTR.0b013e3181c15600 - DOI - PubMed
1. Fleminger S (2003) Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74:857–862. https://doi.org/10.1136/jnnp.74.7.857 - DOI - PubMed - PMC
1. Luukinen H, Viramo P, Herala M et al (2005) Fall-related brain injuries and the risk of dementia in elderly people: a population-based study. Eur J Neurol 12:86–92. https://doi.org/10.1111/j.1468-1331.2004.00953.x - DOI - PubMed
1. Mortimer JA, Van Duijn CM, Chandra V et al (1991) Head trauma as a risk factor for alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 20:S28–S35. https://doi.org/10.1093/ije/20.Supplement_2.S28 - DOI - PubMed

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[1] Matthews KA, Xu W, Gaglioti AH et al (2019) Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years. Alzheimers Dement 15:17–24. https://doi.org/10.1016/j.jalz.2018.06.3063 - DOI - PubMed

[2] Matthews KA, Xu W, Gaglioti AH et al (2019) Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years. Alzheimers Dement 15:17–24. https://doi.org/10.1016/j.jalz.2018.06.3063 - DOI - PubMed

[3] Bazarian JJ, Cernak I, Noble-Haeusslein L et al (2009) Long-term neurologic outcomes after traumatic brain injury. J Head Trauma Rehabil 24:439–451. https://doi.org/10.1097/HTR.0b013e3181c15600 - DOI - PubMed

[4] Bazarian JJ, Cernak I, Noble-Haeusslein L et al (2009) Long-term neurologic outcomes after traumatic brain injury. J Head Trauma Rehabil 24:439–451. https://doi.org/10.1097/HTR.0b013e3181c15600 - DOI - PubMed

[5] Fleminger S (2003) Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74:857–862. https://doi.org/10.1136/jnnp.74.7.857 - DOI - PubMed - PMC

[6] Fleminger S (2003) Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74:857–862. https://doi.org/10.1136/jnnp.74.7.857 - DOI - PubMed - PMC

[7] Luukinen H, Viramo P, Herala M et al (2005) Fall-related brain injuries and the risk of dementia in elderly people: a population-based study. Eur J Neurol 12:86–92. https://doi.org/10.1111/j.1468-1331.2004.00953.x - DOI - PubMed

[8] Luukinen H, Viramo P, Herala M et al (2005) Fall-related brain injuries and the risk of dementia in elderly people: a population-based study. Eur J Neurol 12:86–92. https://doi.org/10.1111/j.1468-1331.2004.00953.x - DOI - PubMed

[9] Mortimer JA, Van Duijn CM, Chandra V et al (1991) Head trauma as a risk factor for alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 20:S28–S35. https://doi.org/10.1093/ije/20.Supplement_2.S28 - DOI - PubMed

[10] Mortimer JA, Van Duijn CM, Chandra V et al (1991) Head trauma as a risk factor for alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 20:S28–S35. https://doi.org/10.1093/ije/20.Supplement_2.S28 - DOI - PubMed

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Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review

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Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review

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