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Randomized Controlled Trial
. 2023 Sep;27(3):427-432.
doi: 10.1007/s10006-022-01081-y. Epub 2022 Jun 1.

Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars

Megarasu Deepanjali  1 , Tangutur Srinivasa Prasad  2 , Pedamally Manodh  2
Affiliations
Randomized Controlled Trial

Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars

Megarasu Deepanjali et al. Oral Maxillofac Surg. 2023 Sep.

Abstract

Purpose: The aim of this study was to assess the efficacy of simvastatin in bone regeneration in extraction sockets of mandibular third molars using cone beam computed tomography (CBCT) at 6th post-operative month.

Methods: This is a prospective randomized split-mouth study involving 15 patients who underwent surgical extraction of bilaterally impacted mandibular third molars with similar morphology on the same day. The efficacy of drug was analyzed by implanting 10 mg of simvastatin into the socket (study site) and observations were made over 6 months to compare the healing with the control site.

Results: The study results demonstrated a statistically significant difference in bone regeneration: mean gray value of 429.133 in study site compared with mean gray value of 310.153 in the control site.

Conclusion: These values demonstrate significant change in bone regeneration in simvastatin site as compared to that of control site.

Keywords: Bone morphogenetic protein; Gelatin sponge; Simvastatin.

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References

    1. Bergman P, Linde C, Pütsep K, Pohanka A, Normark S, Henriques-Normark B et al (2011) Studies on the antibacterial effects of statins - in vitro and in vivo. PLoS ONE 6(8):e24394. https://doi.org/10.1371/journal.pone.0024394 - DOI - PubMed - PMC
    1. Chauhan AS, Maria A, Managutti A (2015) Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars: a clinical pilot study. Journal of maxillofacial and oral surgery 14(3):578–585 - DOI - PubMed
    1. Degala S, Bathija NA (2018) Evaluation of the efficacy of simvastatin in bone regeneration after surgical removal of bilaterally impacted third molars-a split-mouth randomized clinical trial. J Oral Maxillofac Surg 76(9):1847–1858. https://doi.org/10.1016/j.joms.2018.04.035 - DOI - PubMed
    1. Encarnação IC, Xavier CC, Bobinski F et al (2016) Analysis of bone repair and inflammatory process caused by simvastatin combined with PLGA+ HA+ βTCP Scaffold. Implant Dent 25(1):140–148 - DOI - PubMed
    1. Gutierrez GE, Lalka D, Garrett IR et al (2006) Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporos Int 17(7):1033–1042 - DOI - PubMed

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