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. 2022 Oct;27(7):2701-2711.
doi: 10.1007/s40519-022-01412-8. Epub 2022 Jun 1.

Multidisciplinary residential program for the treatment of obesity: how body composition assessed by DXA and blood chemistry parameters change during hospitalization and which variations in body composition occur from discharge up to 1-year follow-up

Clara Gasparri  1 , Simone Perna  2 , Gabriella Peroni  3 , Antonella Riva  4 , Giovanna Petrangolini  4 , Milena Anna Faliva  3 , Maurizio Naso  3 , Mariangela Rondanelli  5   6
Affiliations

Multidisciplinary residential program for the treatment of obesity: how body composition assessed by DXA and blood chemistry parameters change during hospitalization and which variations in body composition occur from discharge up to 1-year follow-up

Clara Gasparri et al. Eat Weight Disord. 2022 Oct.

Abstract

Purpose: Obesity is a chronic disease characterized by a complex variable clinical presentation with comorbidities. A multidisciplinary residential program (MRP) represents one of the best options for treating obesity. The purpose of this study was to evaluate the effectiveness of 8-week MRP on weight loss, body composition assessed by DXA, and metabolic blood parameters between entry (T0) and discharge (T1). The secondary endpoint was the evaluation of the patients' adherence to diet during the check-up outpatient visits, at 2 (T2), 6 (T3), and 12 (T4) months after discharge.

Methods: 168 subjects were enrolled (61 males and 117 females, aged 58.5 ± 13 years, BMI 41.3 ± 6 kg/m2) in the study. The difference in values ​​(end of hospitalization compared to baseline) was calculated through the univariate analysis procedure, which provides regression analysis and analysis of variance for a variable dependent on one or more variables.

Results: There was a statistically significant improvement of all parameters investigated: total mass (- 5.68 kg), fat mass (- 4416.85 g), fat mass index (- 1724.56), visceral adipose tissue (- 332.76 g), arm circumference (- 1.63 cm) and calf circumference (- 1.16 cm). As it is reasonable to expect, even the fat free mass has been reduced (- 1236.03 g); however, the skeletal muscle index was not affected. Statistically significant improvement in glycaemic and lipid profile were reported. The BMI average reduction continued from discharge until T4. No statistically significant changes in fat free mass and visceral adipose tissue (VAT) were reported during a year of follow-up.

Conclusions: The present study demonstrated the clinical benefits of 8-week MRP, which includes hypocaloric diet, physical exercise, and psychological support.

Level of evidence: III, evidence obtained from cohort or case-control analytic studies.

Keywords: Body composition; Hospitalization; Multidisciplinary residential program; Obesity.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Body composition network analysis
Fig. 2
Fig. 2
Changes in body composition during the hospitalization period
Fig. 3
Fig. 3
Changes in body weight, body mass index, fat mass, and VAT for 1-year follow-up
See this image and copyright information in PMC

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