Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov;24(11):1377-1385.
doi: 10.1007/s11912-022-01303-2. Epub 2022 Jun 1.

All-Cause Mortality Risk Prediction in Older Adults with Cancer: Practical Approaches and Limitations

Affiliations
Review

All-Cause Mortality Risk Prediction in Older Adults with Cancer: Practical Approaches and Limitations

Andrea Perez-de-Acha et al. Curr Oncol Rep. 2022 Nov.

Abstract

Purpose of review: The prediction of all-cause mortality is an important component of shared decision-making across the cancer care continuum, particularly in older adults with limited life expectancy, for whom there is an increased risk of over-diagnosis and treatment.

Recent findings: Currently, several international societies recommend the use of all-cause mortality risk prediction tools when making decisions regarding screening and treatment in geriatric oncology. Here, we review some practical aspects of the utilization of those tools and dissect the characteristics of those most employed in geriatric oncology, highlighting both their advantages and their limitations.

Keywords: Cancer; Clinical decision rules; Decision-making; Life expectancy; Mortality; Older adults; Prognosis.

PubMed Disclaimer

Similar articles

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Lee SJ, Lindquist K, Segal MR, Covinsky KE. Development and validation of a prognostic index for 4-year mortality in older adults. JAMA. 2006;295(7):801–8. https://doi.org/10.1001/jama.295.7.801 . - PubMed
    1. Mariotto AB, Noone A-M, Howlader N, Cho H, Keel GE, Garshell J, et al. Cancer survival: an overview of measures, uses, and interpretation. J Natl Cancer Inst Monogr. 2014;2014(49):145–86. https://doi.org/10.1093/jncimonographs/lgu024 . - PubMed - PMC
    1. Berry SD, Ngo L, Samelson EJ, Kiel DP. Competing risk of death: an important consideration in studies of older adults. J Am Geriatr Soc. 2010;58(4):783–7. https://doi.org/10.1111/j.1532-5415.2010.02767.x . - PubMed - PMC
    1. Gómez-Moreno C, Pilleron S, Neuendorff NR, Soto-Perez-de-Celis E. How we use noncancer-specific survival prediction in geriatric oncology: a Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative. J Geriatr Oncol. 2021. https://doi.org/10.1016/j.jgo.2021.10.005 . - PubMed
    1. Lambden J, Zhang B, Friedlander R, Prigerson HG. Accuracy of oncologists’ life-expectancy estimates recalled by their advanced cancer patients: correlates and outcomes. J Palliat Med. 2016;19(12):1296–303. https://doi.org/10.1089/jpm.2016.0121 . - PubMed - PMC

LinkOut - more resources