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Observational Study
. 2022 Sep:122:152-154.
doi: 10.1016/j.ijid.2022.05.055. Epub 2022 May 29.

Risk Factors Associated with Severe/Critical COVID-19 in People Living with HIV-1

Antoine Bachelard  1 , Aurelie Sautereau  2 , Marc Digumber  2 , Valentina Isernia  2 , Bao Phung  2 , Anne-Claire Lehur  2 , Sylvie Le Gac  2 , Roland Landman  2 , Yazdan Yazdanpanah  3 , Jade Ghosn  3
Affiliations
Observational Study

Risk Factors Associated with Severe/Critical COVID-19 in People Living with HIV-1

Antoine Bachelard et al. Int J Infect Dis. 2022 Sep.

Abstract

Introduction: Our objective was to determine the risk factors of a "severe/critical" form of COVID-19 in a cohort of people living with HIV-1 (PLWH1) followed in the Bichat University Hospital center in PARIS, FRANCE.

Methods: This study was an observational retrospective monocentric cohort of PLWH1 diagnosed with COVID-19 between February 1 st and November 31 st, 2020. Risk factors associated with "severe/critical" forms were determined using stepwise forward selection.

Results: One-hundred-and-twenty-nine PLWH1 with COVID-19 were included. COVID-19 diagnosis was confirmed in 98 cases (75.9%) and deemed probable according to the association of clinical criteria and contact case in 31 cases (24.1%). Clinical presentation of COVID-19 was "asymptomatic/mild/moderate" in 95 (73.6%), "severe" in 26 (21.7%) and "critical" in eight (6%). Patients with "severe/critical" COVID-19 tended to be older (median 54 year old), have a higher BMI (median 28.8 kg/m²) and were likely to have diabetes (9 versus 5) or chronic kidney disease (5 versus 2). Transgender women had higher risk too (OR: 4.9 (IC95: 1.35-24.0)). No association was observed between severity of COVID-19 and viral suppression or CD4 rates.

Conclusion: Risk factors for severe COVID-19 were similar in PLWH1 than in the general population and PLWH1 transgender women were at higher risk.

Keywords: COVID-19; HIV; Risk factors.

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Conflict of interest statement

Declaration of Competing Interest The authors have no competing interest to declare.

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