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Review
. 2022 May 16:12:851140.
doi: 10.3389/fcimb.2022.851140. eCollection 2022.

Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota

Anjana  1 , Santosh Kumar Tiwari  1
Affiliations
Review

Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota

Anjana et al. Front Cell Infect Microbiol. .

Abstract

Several strains of lactic acid bacteria are potent probiotics and can cure a variety of diseases using different modes of actions. These bacteria produce antimicrobial peptides, bacteriocins, which inhibit or kill generally closely related bacterial strains and other pathogenic bacteria such as Listeria, Clostridium, and Salmonella. Bacteriocins are cationic peptides that kill the target cells by pore formation and the dissipation of cytosolic contents, leading to cell death. Bacteriocins are also known to modulate native microbiota and host immunity, affecting several health-promoting functions of the host. In this review, we have discussed the ability of bacteriocin-producing probiotic lactic acid bacteria in the modulation of gut microbiota correcting dysbiosis and treatment/maintenance of a few important human disorders such as chronic infections, inflammatory bowel diseases, obesity, and cancer.

Keywords: bacteriocins; dysbiosis; gut microbiota; immunity; modulation; probiotics.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Bacteriocin-producing probiotic lactic acid bacteria showing several potential functions: (1) inhibition of pathogens, (2) colonization of probiotic bacteria by competitive exclusion, (3) activation of macrophages, natural killer (NK) cells further interact with cancer cells causing apoptosis, (4) immunomodulation, (5) gut–brain axis balancing the gut microbiota, (6) antiobesity activity by reducing the adipose tissue (created in BioRender).
See this image and copyright information in PMC

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