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. 2023 Jan;95(1):e27902.
doi: 10.1002/jmv.27902. Epub 2022 Jun 18.

Re-emerging human monkeypox: A major public-health debacle

Shailendra K Saxena  1   2   3 , Saniya Ansari  1   2 , Vimal K Maurya  1   2 , Swatantra Kumar  1   2 , Amita Jain  1   4 , Janusz T Paweska  2   5 , Anil K Tripathi  1 , Ahmed S Abdel-Moneim  2   6   7
Affiliations

Re-emerging human monkeypox: A major public-health debacle

Shailendra K Saxena et al. J Med Virol. 2023 Jan.

Abstract

A multicountry outbreak of the monkeypox virus has gained global attention. As of May 25, 250 confirmed human monkeypox cases have been reported globally. Monkeypox is caused by the Monkeypox virus, which belongs to the Orthopoxvirus genus and Poxviridae family. Monkeypox is often a self-limiting infection, with symptoms lasting 2-4 weeks with the case fatality ratio around 3%-6%. Monkeypox is transmitted to humans by direct contact with an infected person or animal or contact with virus-contaminated material. Human monkeypox infections may lead to various medical complications such as fever, rash, and lymphadenopathies. Pneumonitis, encephalitis, sight-threatening keratitis, and subsequent bacterial infections are all possible complications of monkeypox. An antiviral agent developed to treat smallpox has also been approved for use in the treatment of monkeypox in the United States. Vaccines used in the smallpox eradication program also provided immunity to monkeypox. Newer vaccines have been developed, one of which has been approved for monkeypox prevention. In this study, we provide information about the recent outbreaks of human monkeypox, epidemiology, transmission pattern, possible diagnosis techniques, therapeutics, and available preventive strategies.

Keywords: diagnosis; human; monkeypox; re-emergence; treatment.

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Comment in

  • Monkeypox in a 71-year-old woman.
    Bruno G, Fabrizio C, Rodano L, Buccoliero GB. Bruno G, et al. J Med Virol. 2023 Jan;95(1):e27993. doi: 10.1002/jmv.27993. Epub 2022 Jul 20. J Med Virol. 2023. PMID: 35831136 No abstract available.

References

REFERENCES

    1. Centers for Disease Control and Prevention. Monkeypox. Accessed May 25, 2022. https://www.cdc.gov/poxvirus/monkeypox/about.html
    1. Alakunle E, Moens U, Nchinda G, Okeke MI. Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution. Viruses. 2020;12(11):1257. doi:10.3390/v12111257
    1. Beer EM, Rao VB. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLoS Negl Trop Dis. 2019;13(10):e0007791. doi:10.1371/journal.pntd.0007791
    1. Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human monkeypox-a potential threat? A systematic review. PLoS Negl Trop Dis. 2022;16(2):e0010141. doi:10.1371/journal.pntd.0010141
    1. Kugelman JR, Johnston SC, Mulembakani PM, et al. Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo. Emerg Infect Dis. 2014;20(2):232-239. doi:10.3201/eid2002.130118

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