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Editorial
. 2022 Jun 2;12(6):1413-1415.
doi: 10.1158/2159-8290.CD-22-0301.

Packing a Punch against PD-L1

Claudia Capparelli  1   2 , Andrew E Aplin  1   2
Affiliations
Editorial

Packing a Punch against PD-L1

Claudia Capparelli et al. Cancer Discov. .

Abstract

Antibodies targeting immune checkpoints have made major advances in cancer therapy, but their use can be limited by immune-related adverse effects. The introduction of small-molecule immune-checkpoint inhibitors represents an alternative to improve the current antibody-based immune therapies. See related article by Koblish et al., p. 1482 (3).

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  • Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
    Koblish HK, Wu L, Wang LS, Liu PCC, Wynn R, Rios-Doria J, Spitz S, Liu H, Volgina A, Zolotarjova N, Kapilashrami K, Behshad E, Covington M, Yang YO, Li J, Diamond S, Soloviev M, O'Hayer K, Rubin S, Kanellopoulou C, Yang G, Rupar M, DiMatteo D, Lin L, Stevens C, Zhang Y, Thekkat P, Geschwindt R, Marando C, Yeleswaram S, Jackson J, Scherle P, Huber R, Yao W, Hollis G. Koblish HK, et al. Cancer Discov. 2022 Jun 2;12(6):1482-1499. doi: 10.1158/2159-8290.CD-21-1156. Cancer Discov. 2022. PMID: 35254416 Free PMC article. Clinical Trial.

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