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. 2023 Feb;19(2):658-670.
doi: 10.1002/alz.12694. Epub 2022 Jun 2.

Global estimates on the number of persons across the Alzheimer's disease continuum

Anders Gustavsson  1 , Nicholas Norton  2 , Thomas Fast  2 , Lutz Frölich  3 , Jean Georges  4 , Drew Holzapfel  5 , Tunahan Kirabali  6 , Pierre Krolak-Salmon  7 , Paolo M Rossini  8 , Maria Teresa Ferretti  9 , Lydia Lanman  10 , Antonella Santuccione Chadha  6 , Wiesje M van der Flier  11
Affiliations

Global estimates on the number of persons across the Alzheimer's disease continuum

Anders Gustavsson et al. Alzheimers Dement. 2023 Feb.

Abstract

Introduction: Global estimates on numbers of persons in early stages of Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet are needed to inform policy decisions on preventive measures and planning for future therapies targeting AD pathology.

Methods: We synthesized the literature on prevalence across the AD continuum and derived a model estimating the number of persons, stratified by 5-year age groups, sex, and disease stage (AD dementia, prodromal AD, and preclinical AD).

Results: The global number of persons with AD dementia, prodromal AD, and preclinical AD were estimated at 32, 69, and 315 million, respectively. Together they constituted 416 million across the AD continuum, or 22% of all persons aged 50 and above.

Discussion: Considering predementia stages, the number of persons with AD is much larger than conveyed in available literature. Our estimates are uncertain, especially for predementia stages in low- and middle-income regions where biomarker studies are missing.

Keywords: Alzheimer's disease; preclinical; prevalence; prevention; prodromal.

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References

REFERENCES

    1. Alzheimer's Disease International, World Alzheimer Report 2015 The global impact of dementia. 2015. London.
    1. Wimo A, Guerchet M, Ali G-C, et al. The worldwide costs of dementia 2015 and comparisons with 2010. Alzheimers & Dement. 2017;13(1):1-7.
    1. Collaborators, G.B.D.D.F. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105-e125.
    1. G. B. D. Dementia collaborators, global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(1):88-106.
    1. G. B. D. Diseases injuries collaborators, global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1204-1222.

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