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Review
. 2022 Jul;123(7):1133-1147.
doi: 10.1002/jcb.30293. Epub 2022 Jun 2.

SUMOylation in peripheral tissues under low perfusion-related pathological states

Filipe R M B Oliveira  1   2 , Ericks S Soares  1   2 , Christoph Harms  3   4   5   6 , Helena I Cimarosti  1   2   7 , Regina Sordi  1   2
Affiliations
Review

SUMOylation in peripheral tissues under low perfusion-related pathological states

Filipe R M B Oliveira et al. J Cell Biochem. 2022 Jul.

Abstract

SUMOylation is described as a posttranslational protein modification (PTM) that is involved in the pathophysiological processes underlying several conditions related to ischemia- and reperfusion-induced damage. Increasing evidence suggests that, under low oxygen levels, SUMOylation might be part of an endogenous mechanism, which is triggered by injury to protect cells within the central nervous system. However, the role of ischemia-induced SUMOylation in the periphery is still unclear. This article summarizes the results of recent studies regarding SUMOylation profiles in several diseases characterized by impaired blood flow to the cardiorenal, gastrointestinal, and respiratory systems. Our review shows that although ischemic injury per se does not always increase SUMOylation levels, as seen in strokes, it seems that in most cases the positive modulation of protein SUMOylation after peripheral ischemia might be a protective mechanism. This complex relationship warrants further investigation, as the role of SUMOylation during hypoxic conditions differs from organ to organ and is still not fully elucidated.

Keywords: SUMO1; SUMO2/3; heart; ischemia; kidney; lungs; reperfusion.

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References

REFERENCES

    1. Wu M-Y, Yiang G-T, Liao W-T, et al. Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem. 2018;46(4):1650-1667. doi:10.1159/000489241
    1. Rodriguez C, Agulla J, Delgado-Esteban M. Refocusing the brain: new approaches in neuroprotection against ischemic injury. Neurochem Res. 2021;46(1):51-63. doi:10.1007/s11064-020-03016-z
    1. Mahajan R, Delphin C, Guan T, Gerace L, Melchior F. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell. 1997;88(1):97-107. doi:10.1016/S0092-8674(00)81862-0
    1. Matunis MJ, Coutavas E, Blobel G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol. 1996;135(6):1457-1470. doi:10.1083/jcb.135.6.1457
    1. Celen AB, Sahin U. Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts. FEBS J. 2020;287(15):3110-3140. doi:10.1111/febs.15319

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