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. 2022 Jun 3;376(6597):1055-1056.
doi: 10.1126/science.abn4016. Epub 2022 Jun 2.

Principles of emotional brain circuit maturation

Matthew T Birnie  1 , Tallie Z Baram  1
Affiliations

Principles of emotional brain circuit maturation

Matthew T Birnie et al. Science. .

Abstract

Early-life environmental signals contribute to how the brain handles reward, stress, and fear.

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Figures

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Learning from sensory and memory circuits
Maturation principles of sensory (e.g., visual, somatosensory, and auditory) and memory circuits are instructive for how environmental signals influence emotion circuit development. The building blocks and organization of emotion circuits include components of sensory and memory circuits, and of signals providing information about internal body states (hunger, fatigue, cold). Cortical and subcortical components process these inputs in emotion-related circuits (teal). A1, auditory cortex; CN, cochlear nucleus; DG, dentate gyrus; IC, inferior colliculus; LEC, lateral entorhinal cortex; MEC, medial entorhinal cortex; NAc, nucleus accumbens; PFC, prefrontal cortex; S1/S2, somatosensory 1/2 cortex; V1/V2, visual 1/2 cortex; VTA, ventral tegmental area.
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