Immune memory to SARS-CoV-2 Omicron BA.1 breakthrough infections: To change the vaccine or not?

Menno C van Zelm^{1

2}

Affiliations

¹ Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
² Department of Allergy, Immunology, and Respiratory Medicine, Central Clinical School, Monash University and Alfred Hospital, Melbourne, VIC, Australia. Email: menno.vanzelm@monash.edu.

Comment

Menno C van Zelm. Sci Immunol. 2022.

. 2022 Aug 26;7(74):eabq5901.

doi: 10.1126/sciimmunol.abq5901. Epub 2022 Aug 26.

Menno C van Zelm^{1

2}

¹ Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
² Department of Allergy, Immunology, and Respiratory Medicine, Central Clinical School, Monash University and Alfred Hospital, Melbourne, VIC, Australia. Email: menno.vanzelm@monash.edu.

Abstract

Analysis of memory B cell responses to Spike antigen after Omicron BA.1 breakthrough infections suggests that "original antigenic sin" is in play.

Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection.
Kaku CI, Bergeron AJ, Ahlm C, Normark J, Sakharkar M, Forsell MNE, Walker LM. Kaku CI, et al. Sci Immunol. 2022 Jul 29;7(73):eabq3511. doi: 10.1126/sciimmunol.abq3511. Epub 2022 Jul 29. Sci Immunol. 2022. PMID: 35549299 Free PMC article.
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes.
Quandt J, Muik A, Salisch N, Lui BG, Lutz S, Krüger K, Wallisch AK, Adams-Quack P, Bacher M, Finlayson A, Ozhelvaci O, Vogler I, Grikscheit K, Hoehl S, Goetsch U, Ciesek S, Türeci Ö, Sahin U. Quandt J, et al. Sci Immunol. 2022 Sep 16;7(75):eabq2427. doi: 10.1126/sciimmunol.abq2427. Epub 2022 Sep 16. Sci Immunol. 2022. PMID: 35653438 Free PMC article.