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. 2022 Aug 25;140(8):809-814.
doi: 10.1182/blood.2021014527.

Anticoagulation in hospitalized patients with COVID-19

Lisa Baumann Kreuziger  1 , Michelle Sholzberg  2   3 , Mary Cushman  2   4
Affiliations

Anticoagulation in hospitalized patients with COVID-19

Lisa Baumann Kreuziger et al. Blood. .

Abstract

Coronavirus disease-19 (COVID-19) includes a thromboinflammatory syndrome that may manifest with microvascular and macrovascular thrombosis. Patients with COVID-19 have a higher incidence of venous thromboembolism than other hospitalized patients. Three randomized control trials suggesting benefit of therapeutic heparin in hospitalized noncritically ill patients with COVID-19 have led to conditional guideline recommendations for this treatment. By contrast, prophylactic-dose heparin is recommended for critically ill patients. Unprecedented collaboration and rapidly funded research have improved care of hospitalized patients with COVID-19.

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Figures

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Graphical abstract
Figure 1.
Figure 1.
Meta-analysis of randomized control trials of therapeutic heparin in hospitalized noncritically ill patients with COVID-19. Odds ratios of 3 trials were combined with Mantel-Haenszel fixed-effect meta-analyses. Treatment effects are represented by squares with area proportional to the trial weight with 95% confidence interval shown by horizontal lines. Diamonds show the meta-analyses treatment effect estimates. Reproduced with permission from Research and Practice in Thrombosis and Haemostasis.
See this image and copyright information in PMC

References

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