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. 2022 May 17:10:905108.
doi: 10.3389/fchem.2022.905108. eCollection 2022.

New Sesquiterpenoids From Plant-Associated Irpex lacteus

Huai-Zhi Luo  1   2 , Huan Jiang  2 , Xi-Shan Huang  3 , Ai-Qun Jia  1
Affiliations

New Sesquiterpenoids From Plant-Associated Irpex lacteus

Huai-Zhi Luo et al. Front Chem. .

Erratum in

Abstract

Bacteria produce a large number of virulence factors through the quorum sensing (QS) mechanism. Inhibiting such QS system of the pathogens without disturbing their growth is a potential strategy to control multi-drug-resistant pathogens. To accomplish this, two new tremulane-type sesquiterpenoids, irpexolaceus H (1) and I (2), along with two known furan compounds, irpexlacte B (3) and C (4), were isolated from Orychophragmus violaceus (L.) OE Schulz endophytic fungus Irpex lacteus (Fr.) Fr. Their structures were elucidated by detailed spectroscopic data (NMR, HRESIMS, IR, and UV), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analysis. Furthermore, those compounds were evaluated for anti-quorum sensing (anti-QS) activity, and compound 3 was found contributing to the potential QS inhibitory activity.

Keywords: Irpex lacteus (Fr.) Fr; Orychophragmus violaceus (L.) O.E. Schulz; furan; quorum sensing; sesquiterpenoids.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structures of 1–4.
FIGURE 2
FIGURE 2
Key 1H–1H COSY (formula image), HMBC (formula image), and NOESY (formula image) correlations of 1 and 2.
FIGURE 3
FIGURE 3
Perspective ORTEP drawing for 1.
FIGURE 4
FIGURE 4
Experimental and calculated ECD spectra of 2.
FIGURE 5
FIGURE 5
Proposed biosynthetic pathway for 1 and 2.
FIGURE 6
FIGURE 6
Screening of QS inhibitory activity by C. violaceum CV026 (A) and A. tumefaciens A136 (B). Compounds 1 (A), 2 (B), 3 (C), and 4 (D).
See this image and copyright information in PMC

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