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. 2022 Jan-Dec:37:15333175221104354.
doi: 10.1177/15333175221104354.

A Functional Assessment Tool to Distinguish Controls From Alzheimer's Disease in Lima, Peru

Nilton Custodio  1   2   3   4 , Rosa Montesinos  2   3   5 , Diego Chambergo-Michilot  6 , Eder Herrera-Perez  2   3   7 , Maritza Pintado-Caipa  1   2   3   8 , Wendy Seminario G  1   2   3 , José Cuenca  2   3   9   10 , Laura Mesía  2   3 , Virgilio E Failoc-Rojas  2   3   11 , Monica M Diaz  12   13
Affiliations

A Functional Assessment Tool to Distinguish Controls From Alzheimer's Disease in Lima, Peru

Nilton Custodio et al. Am J Alzheimers Dis Other Demen. 2022 Jan-Dec.

Abstract

Background: The Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer's disease (ad). We evaluated its performance in controls, Peruvians with MCI or AD.

Methods: A cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), ad or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach's alpha) and validity were assessed.

Results: We enrolled 276 individuals (ad: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC: .996), and Cronbach's alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate ad severity. The ADCS-ADL correlated highly with nearly all tools.

Conclusions: The ADCS-ADL scale is reliable in a population with ad in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.

Keywords: alzheimer disease; dementia; neurocognitive disorders; peru; validation study.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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