Genomic biomarkers to guide precision radiotherapy in prostate cancer

Abstract

Our ability to prognosticate the clinical course of patients with cancer has historically been limited to clinical, histopathological, and radiographic features. It has long been clear however, that these data alone do not adequately capture the heterogeneity and breadth of disease trajectories experienced by patients. The advent of efficient genomic sequencing has led to a revolution in cancer care as we try to understand and personalize treatment specific to patient clinico-genomic phenotypes. Within prostate cancer, emerging evidence suggests that tumor genomics (e.g., DNA, RNA, and epigenetics) can be utilized to inform clinical decision making. In addition to providing discriminatory information about prognosis, it is likely tumor genomics also hold a key in predicting response to oncologic therapies which could be used to further tailor treatment recommendations. Herein we review select literature surrounding the use of tumor genomics within the management of prostate cancer, specifically leaning toward analytically validated and clinically tested genomic biomarkers utilized in radiotherapy and/or adjunctive therapies given with radiotherapy.

Keywords: biomarkers; genomics; prostate cancer; radiotherapy.

Figure 1.

Decipher genomic classifier within localized prostate cancer GC: Genomic Classifier; OR: Odds Ratio; NPV: Negative Predictive Value; SOC: standard of care; OS: Overall Survival; RT: Radiation Therapy; ADT: Androgen deprivation therapy