Multicenter Study

. 2022 Oct;50(5):1363-1372.

doi: 10.1007/s15010-022-01855-2. Epub 2022 Jun 3.

Long-term neuro-functional disability in adult patients with community-acquired bacterial meningitis

Souade Akroum¹, Sarah Tubiana^{1

2

3}, Thomas de Broucker⁴, Nathalie Dournon⁵, Emmanuelle Varon⁶, Marie Cécile Ploy⁷, Bruno Mourvillier⁸, Eric Oziol⁹, Flore Lacassin¹⁰, Henri Laurichesse¹¹, Bruno Hoen¹², Xavier Duval^{13

14}, Charles Burdet^{1

2

15}; and the COMBAT study group

Collaborators, Affiliations

Collaborators

and the COMBAT study group:
X Duval, B Hoen, B Mourvillier, E Varon, S Tubiana, M C Ploy, F Caron, Pe Bollaert, O Gaillot, Mk Taha, C Poyart, S Bonacorsi, F Vandenesch, E Cambau, M Lecuit, A Gravet, B Frachet, T De Broucker, D Levy Bruhl, F Raffi, B Abraham, F Ader, E Ancel, N Anguel, L Argaud, S Arista, L Armand-Lefevre, M N Bachelier, S Balavoine, R Baraduc, G Barnaud, G Beraud, D Bertei, E Bessede, T Billard Pomares, C Biron, G Blanchard-Marche, S Bland, J Boileau, C Bornstain, S Bourdon, A Bousquet, S Boyer, A Bozorg-Grayeli, L Bret, F Bricaire, E Brocas, M Brun, J Buret, C Burucoa, E Cambau, G Camuset, C Canevet, F Caron, A Carricajo, I Casin, D Cassignard, B Castan, C Cazanave, T Challan-Belval, C Chandesris, V Chanteperdrix-Marillier, C Chaplain, C Charlier-Woerther, H Chaussade, C Chirouze, M Chomarat, Y E Claessens, B Clair, D Combaux, J M Conil, H Cordel, P Cormier, J Cousson, P Cronier, E Cua, V Daneluzzi, A Dao Dubremetz, A Defarcy, N Degand, S Dekeyser, D Delaune, E Denes, D Descamps, J L Desmaretz, E Devaud, M C Di Palma, S Diamantis, J L Diehl, J Dimet, A Dinh, X Duval, E Descloux, J Colot, A Emirian, O Epaulard, L Escaut, C Fabe, T Ferry, H Fiette, C Flateau, N Fonsale, E Forestier, N Fortineau, T Fraisse, F Faibis, M Froidure, S Gabriel-Solean, A Gagneux-Brunon, Garandeau, M Garcia, V Garnier, S Gaudry, R Ghozzi, A Gravet, V Gregoire-Faucher, M Grosset, I Gueit, D Guelon, C Guillet Caruba, T Guimard, Y Guimard, J Guinard, T Hadou, J P Helene, S Henard, B Henry, R Hernu, A C Hochart, B Hoen, N Idri, G Illes, X Jacob, S Jaffuel, D Jan, I Jarrin, F Jaureguy, C Joseph, M E Juvin, S Kayal, F Lacassin, M Lafaurie, B Lalanne, I Lamaury, P Lanotte, M F Lartigue, Y Latorre, P Laudat, E Laurens, H Laurichesse, C Le Brun, V Le Moing, P Le Turnier, H Lecuyer, S Ledru, L Legout, C Legrix, A Lemaignen, C Lemble, L Lemee, S Leotard, O Lesens, P Lesprit, M Levast, F Louis, L Quaesaet, N Luizy, S Males, E Malpote, G Martin-Blondel, V Martinez, R Masson, O Matray, A Mbadi, F Mechai, A Merens, M C Meyohas, G Michel, A Michon, J Mootien Yoganaden, D Morquin, S Mouly, N Mrozek, S Nguyen, Y Nguyen, A Odinotte, M Ogielska, E Oziol, B Page, E Parisi-Duchene, T Pasdeloup, S Patrat-Delon, I Patry, A Pechinot, I Pelloux, S Picot, J Pierre, L Piroth, C Plassart, P Plessis, C Ploton, M C Ploy, L Portel, M Poupard, C Poyart, T Prazuck, F Raffi, A Ramanantsoa, C Rapp, L Raskine, J Raymond, M Revest, A Riche, S Robaday-Voisin, F Robin, F Roblot, J P Romaszko, F Rousseau, A L Roux, C Royer, M Saada, D Salmon, C Saroufim, J L Schmit, M Sebire, C Segonds, F Sifaoui, V Sivadon-Tardy, N Soismier, K Solen, A Sommabere, O Son, J P Stahl, R Steux, S Sunder, F Suy, D Tande, J Tankovic, S Tigaud, B Tourrand, N Valin, N Van Grunderbeeck, F Vandenesch, E Varon, R Vatan, C Venot, M Vergnaud, Vernet, M Vidal, V Vitrat, D Vittecoq, F Vuotto, A Chabrol, J Cabalion, Isabelle Gorenne, Cédric Laouenan, Estelle Marcault, France Mentre, Blandine Pasquet, Carine Roy, Sarah F Mentré Tubiana, C Laouenan, I Gorenne, E Marcault, P Manchon, B Pasquet, C Roy

Affiliations

¹ Centre d'Investigation Clinique, Hôpital Bichat Claude Bernard, AP-HP, Hôpital Bichat, Inserm CIC 1425, 46, rue Henri Huchard, 75018, Paris, France.
² Université Paris Cité, IAME, INSERM, 75018, Paris, France.
³ Centre de Ressources Biologiques, AP-HP, Hôpital Bichat, 75018, Paris, France.
⁴ Service de Neurologie, Hôpital Delafontaine, 93200, Saint-Denis, France.
⁵ Service de maladies infectieuses et tropicales, dermatologie, médecine interne, Centre Hospitalier Universitaire de Pointe-à-Pitre, 97159, Pointe-à-Pitre, France.
⁶ Centre Hospitalier Intercommunal de Créteil, Centre National de Référence des Pneumocoques, 94010, Créteil, France.
⁷ Centre Hospitalier Universitaire de Limoges, Observatoire Régional des Pneumocoques, 87000, Limoges, France.
⁸ Service de Médecine Intensive et Réanimation Polyvalente, CHU Reims, 51100, Reims, France.
⁹ Service de Médecine Interne, Centre Hospitalier de Béziers, 34500, Béziers, France.
¹⁰ Service de Médecine Interne, Centre Hospitalier Territorial de Nouméa, 98849, Nouméa, France.
¹¹ Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Clermont-Ferrand, 63003, Clermont-Ferrand, France.
¹² Service de Maladies Infectieuses et Tropicales, CHU de Nancy, Hôpitaux de Brabois, 54511, Vandoeuvre-lès-Nancy, France.
¹³ Centre d'Investigation Clinique, Hôpital Bichat Claude Bernard, AP-HP, Hôpital Bichat, Inserm CIC 1425, 46, rue Henri Huchard, 75018, Paris, France. xavier.duval@aphp.fr.
¹⁴ Université Paris Cité, IAME, INSERM, 75018, Paris, France. xavier.duval@aphp.fr.
¹⁵ Département d'Epidémiologie, Biostatistique et Recherche, AP-HP, Hôpital Bichat, 75018, Paris, France.

PMID: 35657529
DOI: 10.1007/s15010-022-01855-2

Multicenter Study

Long-term neuro-functional disability in adult patients with community-acquired bacterial meningitis

Souade Akroum et al. Infection. 2022 Oct.

. 2022 Oct;50(5):1363-1372.

doi: 10.1007/s15010-022-01855-2. Epub 2022 Jun 3.

Authors

Collaborators

and the COMBAT study group:
X Duval, B Hoen, B Mourvillier, E Varon, S Tubiana, M C Ploy, F Caron, Pe Bollaert, O Gaillot, Mk Taha, C Poyart, S Bonacorsi, F Vandenesch, E Cambau, M Lecuit, A Gravet, B Frachet, T De Broucker, D Levy Bruhl, F Raffi, B Abraham, F Ader, E Ancel, N Anguel, L Argaud, S Arista, L Armand-Lefevre, M N Bachelier, S Balavoine, R Baraduc, G Barnaud, G Beraud, D Bertei, E Bessede, T Billard Pomares, C Biron, G Blanchard-Marche, S Bland, J Boileau, C Bornstain, S Bourdon, A Bousquet, S Boyer, A Bozorg-Grayeli, L Bret, F Bricaire, E Brocas, M Brun, J Buret, C Burucoa, E Cambau, G Camuset, C Canevet, F Caron, A Carricajo, I Casin, D Cassignard, B Castan, C Cazanave, T Challan-Belval, C Chandesris, V Chanteperdrix-Marillier, C Chaplain, C Charlier-Woerther, H Chaussade, C Chirouze, M Chomarat, Y E Claessens, B Clair, D Combaux, J M Conil, H Cordel, P Cormier, J Cousson, P Cronier, E Cua, V Daneluzzi, A Dao Dubremetz, A Defarcy, N Degand, S Dekeyser, D Delaune, E Denes, D Descamps, J L Desmaretz, E Devaud, M C Di Palma, S Diamantis, J L Diehl, J Dimet, A Dinh, X Duval, E Descloux, J Colot, A Emirian, O Epaulard, L Escaut, C Fabe, T Ferry, H Fiette, C Flateau, N Fonsale, E Forestier, N Fortineau, T Fraisse, F Faibis, M Froidure, S Gabriel-Solean, A Gagneux-Brunon, Garandeau, M Garcia, V Garnier, S Gaudry, R Ghozzi, A Gravet, V Gregoire-Faucher, M Grosset, I Gueit, D Guelon, C Guillet Caruba, T Guimard, Y Guimard, J Guinard, T Hadou, J P Helene, S Henard, B Henry, R Hernu, A C Hochart, B Hoen, N Idri, G Illes, X Jacob, S Jaffuel, D Jan, I Jarrin, F Jaureguy, C Joseph, M E Juvin, S Kayal, F Lacassin, M Lafaurie, B Lalanne, I Lamaury, P Lanotte, M F Lartigue, Y Latorre, P Laudat, E Laurens, H Laurichesse, C Le Brun, V Le Moing, P Le Turnier, H Lecuyer, S Ledru, L Legout, C Legrix, A Lemaignen, C Lemble, L Lemee, S Leotard, O Lesens, P Lesprit, M Levast, F Louis, L Quaesaet, N Luizy, S Males, E Malpote, G Martin-Blondel, V Martinez, R Masson, O Matray, A Mbadi, F Mechai, A Merens, M C Meyohas, G Michel, A Michon, J Mootien Yoganaden, D Morquin, S Mouly, N Mrozek, S Nguyen, Y Nguyen, A Odinotte, M Ogielska, E Oziol, B Page, E Parisi-Duchene, T Pasdeloup, S Patrat-Delon, I Patry, A Pechinot, I Pelloux, S Picot, J Pierre, L Piroth, C Plassart, P Plessis, C Ploton, M C Ploy, L Portel, M Poupard, C Poyart, T Prazuck, F Raffi, A Ramanantsoa, C Rapp, L Raskine, J Raymond, M Revest, A Riche, S Robaday-Voisin, F Robin, F Roblot, J P Romaszko, F Rousseau, A L Roux, C Royer, M Saada, D Salmon, C Saroufim, J L Schmit, M Sebire, C Segonds, F Sifaoui, V Sivadon-Tardy, N Soismier, K Solen, A Sommabere, O Son, J P Stahl, R Steux, S Sunder, F Suy, D Tande, J Tankovic, S Tigaud, B Tourrand, N Valin, N Van Grunderbeeck, F Vandenesch, E Varon, R Vatan, C Venot, M Vergnaud, Vernet, M Vidal, V Vitrat, D Vittecoq, F Vuotto, A Chabrol, J Cabalion, Isabelle Gorenne, Cédric Laouenan, Estelle Marcault, France Mentre, Blandine Pasquet, Carine Roy, Sarah F Mentré Tubiana, C Laouenan, I Gorenne, E Marcault, P Manchon, B Pasquet, C Roy

Affiliations

¹ Centre d'Investigation Clinique, Hôpital Bichat Claude Bernard, AP-HP, Hôpital Bichat, Inserm CIC 1425, 46, rue Henri Huchard, 75018, Paris, France.
² Université Paris Cité, IAME, INSERM, 75018, Paris, France.
³ Centre de Ressources Biologiques, AP-HP, Hôpital Bichat, 75018, Paris, France.
⁴ Service de Neurologie, Hôpital Delafontaine, 93200, Saint-Denis, France.
⁵ Service de maladies infectieuses et tropicales, dermatologie, médecine interne, Centre Hospitalier Universitaire de Pointe-à-Pitre, 97159, Pointe-à-Pitre, France.
⁶ Centre Hospitalier Intercommunal de Créteil, Centre National de Référence des Pneumocoques, 94010, Créteil, France.
⁷ Centre Hospitalier Universitaire de Limoges, Observatoire Régional des Pneumocoques, 87000, Limoges, France.
⁸ Service de Médecine Intensive et Réanimation Polyvalente, CHU Reims, 51100, Reims, France.
⁹ Service de Médecine Interne, Centre Hospitalier de Béziers, 34500, Béziers, France.
¹⁰ Service de Médecine Interne, Centre Hospitalier Territorial de Nouméa, 98849, Nouméa, France.
¹¹ Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Clermont-Ferrand, 63003, Clermont-Ferrand, France.
¹² Service de Maladies Infectieuses et Tropicales, CHU de Nancy, Hôpitaux de Brabois, 54511, Vandoeuvre-lès-Nancy, France.
¹³ Centre d'Investigation Clinique, Hôpital Bichat Claude Bernard, AP-HP, Hôpital Bichat, Inserm CIC 1425, 46, rue Henri Huchard, 75018, Paris, France. xavier.duval@aphp.fr.
¹⁴ Université Paris Cité, IAME, INSERM, 75018, Paris, France. xavier.duval@aphp.fr.
¹⁵ Département d'Epidémiologie, Biostatistique et Recherche, AP-HP, Hôpital Bichat, 75018, Paris, France.

PMID: 35657529
DOI: 10.1007/s15010-022-01855-2

Abstract

Purpose: To investigate the prevalence of neuro-functional disability and its determinants 12 months after community-acquired bacterial meningitis (CABM) in adult patients.

Methods: In a prospective multicenter cohort study (COMBAT), all consecutive cases of CABM were enrolled and followed up for 12 months. Neuro-functional disability at 12 months was evaluated using a combination of the Glasgow Outcome Scale (functional disability), and the modified Rankin Disability Scale (physical disability). Factors associated with neuro-functional disability were identified by multivariate logistic regression.

Results: Among 281 patients, 84 (29.9%) patients exhibited neuro-functional disability at 12 months: 79 (28.1%) with functional disability and 51 (18.1%) with physical disability. Overall, 6 patients (2.1%) died during the follow-up. The most common pathogen identified was Streptococcus pneumoniae (131/272, 48.2%); 77/268 patients (28.7%) had a physical disability at hospital discharge. Factors independently associated with 12-month neuro-functional disability were a pneumococcal meningitis (adjusted OR = 2.8; 95% confidence interval (CI) = [1.3; 6.7]), the presence of a physical disability at hospital discharge (aOR = 2.3; 95%CI = [1.2; 4.4]) and the presence of behavioral disorders at hospital-discharge (aOR = 5.9; 95%CI = [1.6; 28.4]). Dexamethasone use was not significantly associated with neuro-functional disability (OR = 0.2; 95%CI = [< 0.1;1.3]).

Conclusion: Neuro-functional disability is frequently reported 12 months after CABM. Detailed neurological examination at discharge is needed to improve the follow-up.

Trial registration: NCT01730690.

Keywords: Bacterial meningitidis; Cohort study; Functional disability; Neuro-functional disability; Physical disability.

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References

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Long-term neuro-functional disability in adult patients with community-acquired bacterial meningitis

Collaborators

Affiliations

Long-term neuro-functional disability in adult patients with community-acquired bacterial meningitis

Authors

Collaborators

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources

Full Text Sources

Medical