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Review
. 2022 Jun 3;7(72):eabm2465.
doi: 10.1126/sciimmunol.abm2465. Epub 2022 Jun 3.

The circadian immune system

Chen Wang  1 , Lydia Kay Lutes  1 , Coline Barnoud  1 , Christoph Scheiermann  1   2
Affiliations
Review

The circadian immune system

Chen Wang et al. Sci Immunol. .

Abstract

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were the first to identify immune responses to be under a circadian control. Only in the last decade, however, have the molecular factors governing circadian immune rhythms been identified. These studies have revealed a highly complex picture of the interconnectivity of rhythmicity within immune cells with that of their environment. Here, we provide a global overview of the circadian immune system, focusing on recent advances in the rapidly expanding field of circadian immunology.

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