Selfish antibodies target auto-antigens in cancer

Ángel Garza Reyna¹, Gabriel K Griffin^{1

2}

Affiliations

Comment

Ángel Garza Reyna et al. Sci Immunol. 2022.

. 2022 Jun 3;7(72):eadd2044.

doi: 10.1126/sciimmunol.add2047. Epub 2022 Jun 3.

Ángel Garza Reyna¹, Gabriel K Griffin^{1

2}

Abstract

Auto-antibodies against MMP14 define tumor-reactive humoral responses in ovarian cancer.

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.
Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani O, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Cohen NM, Gershoni JM, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z. Mazor RD, et al. Cell. 2022 Mar 31;185(7):1208-1222.e21. doi: 10.1016/j.cell.2022.02.012. Epub 2022 Mar 18. Cell. 2022. PMID: 35305314