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Comment
. 2022 Jun 2;82(11):1979-1980.
doi: 10.1016/j.molcel.2022.05.017.

Poly(m6A) tails stabilize transcripts

Guillaume Lavergne  1 , Jean-Yves Roignant  2
Affiliations
Free article
Comment

Poly(m6A) tails stabilize transcripts

Guillaume Lavergne et al. Mol Cell. .
Free article

Abstract

Viegas et al. (2022) discover that in Trypanosoma brucei the poly(A) tails of the variant surface glycoprotein (VSG) transcripts are methylated, a mechanism that stabilizes these transcripts and ensures protection against the immune response in mammals.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • N6-methyladenosine in poly(A) tails stabilize VSG transcripts.
    Viegas IJ, de Macedo JP, Serra L, De Niz M, Temporão A, Silva Pereira S, Mirza AH, Bergstrom E, Rodrigues JA, Aresta-Branco F, Jaffrey SR, Figueiredo LM. Viegas IJ, et al. Nature. 2022 Apr;604(7905):362-370. doi: 10.1038/s41586-022-04544-0. Epub 2022 Mar 30. Nature. 2022. PMID: 35355019 Free PMC article.

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