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. 2022 Aug;85(2):e37-e39.
doi: 10.1016/j.jinf.2022.05.035. Epub 2022 Jun 1.

Comparison of SARS-CoV-2 aerosol emission from patients with Omicron BA.1 or BA.2 subvariant infection

Yidun Zhang  1 , Jiaming Li  2 , Lina Jiang  1 , Qi Chen  3 , Yingying Fu  2 , Yifei Jin  2 , Zehui Chen  1 , Fei Tang  1 , Xiaohong Zeng  1 , Huixin Wen  1 , Bing Lu  2 , Li Li  4 , Jing Zheng  5 , Zhongyi Wang  6
Affiliations

Comparison of SARS-CoV-2 aerosol emission from patients with Omicron BA.1 or BA.2 subvariant infection

Yidun Zhang et al. J Infect. 2022 Aug.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare no competing interests.

Figures

Fig 1
Fig. 1
Aerosol emission characteristics of SARS-CoV-2 Omicron BA.1 and BA.2 subvariants, virus growth rates in Caco2 cells, and the relationship between viral load in upper respiratory tract and breath emission rate (BER) of COVID-19 patients. (A) Methods involved in this study, including throat swabs sampling, exhaled breath condensate (EBC) collection and SARS-CoV-2 RNA detection; (B) The proportion of single and double positive EBCs. These data were obtained from 34 patients infected with Omicron BA.1 and 51 patients infected with Omicron BA.2. Single positive means that one of the ORF1ab, N and E genes tests positive and double positive means that any two of the three genes test positive. Light red represents single positive EBCs, dark red represents double positive EBCs and light blue represents negative EBCs; (C) Ct values of throat swabs at admission. The data in the figure are RNA test data of throat swabs from the 85 patients at admission. Blue and red represent ORF1ab gene and N gene of SARS-CoV-2, respectively. Statistical significance between two groups was calculated by unpaired Student's t-test. Values are expressed as the mean ± standard error of the mean (SEM). *P < 0.05, **P <0.01; (D) BER of patients with Omicron BA.1 or BA.2 subvariant infection in early stage (<7days). Orange dots represent each data, the horizontal lines represent maximum value, 25% percentile, 50% percentile (median), 75% percentile and minimum value (from bottom to top), respectively; (E) Growth rates of different SARS-CoV-2 strains in Caco2 cells including BA.1.1, BA.1.17, BA.2.2, BA.2.3, BA.2.10, Delta and WT. The broken lines in different colors represent different SARS-CoV-2 strains; (F) Variation trends of BER and Ct value of throat swabs. Data were obtained from absolute quantitative data of N gene sourced from positive patients. The patients with positive EBCs were divided into two groups, including group high and group low, according to their Ct value of throat swabs. Yellow represents the average Ct value of throat swabs and the blue represents average BER.
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References

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