New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Shanawaj Khair¹, Lisa A Brenner², Michael Koval³, Derrick Samuelson⁴, Jessica A Cucinello-Regland⁵, Paige Anton⁶, Mariann R Piano⁷, Liz Simon⁸, Kathryn Crotty⁹, Farah Sharieh¹⁰, Jeffrey B Travers¹¹, Vaibhav Singh¹², Abigail Cannon¹³, Adam Kim¹², Rebecca L McCullough⁶, Samantha M Yeligar⁹, Todd A Wyatt¹⁴, Rachel H McMahan¹⁵, Mashkoor A Choudhry¹⁶, Elizabeth J Kovacs¹⁷

Affiliations

¹ Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Molecular Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Medical Scientist Training Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.
² VA Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional Veterans Affairs (VA) Medical Center, Aurora, CO, United States; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Department of Psychiatry and Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Military and Veteran Microbiome: Consortium for Research and Education, Aurora, CO, United States.
³ Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, United States.
⁴ Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
⁵ Department of Physiology, Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
⁶ Department of Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.
⁷ Center for Research Development and Scholarship, Vanderbilt University School of Nursing, Nashville, TN, United States.
⁸ Department of Physiology, Comprehensive Alcohol HIV/AIDs Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
⁹ Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Atlanta Veterans Affairs Health Care System, Decatur, GA, United States.
¹⁰ Department of Orthopedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL, United States; Alcohol Research Program, Loyola University Chicago Stritch School of Medicine, Maywood, IL, United States.
¹¹ Wright State University, Dayton VAMC, Dayton, OH, United States.
¹² Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, United States.
¹³ Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Campus, Maywood, IL, United States.
¹⁴ Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, United States.
¹⁵ Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.
¹⁶ Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Campus, Maywood, IL, United States; Integrative Cell Biology Program, Loyola University Chicago Health Sciences Campus, Maywood, IL, United States.
¹⁷ Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Molecular Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Medical Scientist Training Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; VA Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional Veterans Affairs (VA) Medical Center, Aurora, CO, United States. Electronic address: Elizabeth.Kovacs@CUAnschutz.edu.

PMID: 35659577
PMCID: PMC9994264
DOI: 10.1016/j.alcohol.2022.05.004

Review

New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Shanawaj Khair et al. Alcohol. 2022 Sep.

. 2022 Sep:103:1-7.

doi: 10.1016/j.alcohol.2022.05.004. Epub 2022 Jun 1.

Authors

Affiliations

¹ Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Molecular Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Medical Scientist Training Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.
² VA Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional Veterans Affairs (VA) Medical Center, Aurora, CO, United States; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Department of Psychiatry and Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Military and Veteran Microbiome: Consortium for Research and Education, Aurora, CO, United States.
³ Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, United States.
⁴ Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
⁵ Department of Physiology, Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
⁶ Department of Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.
⁷ Center for Research Development and Scholarship, Vanderbilt University School of Nursing, Nashville, TN, United States.
⁸ Department of Physiology, Comprehensive Alcohol HIV/AIDs Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
⁹ Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Atlanta Veterans Affairs Health Care System, Decatur, GA, United States.
¹⁰ Department of Orthopedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL, United States; Alcohol Research Program, Loyola University Chicago Stritch School of Medicine, Maywood, IL, United States.
¹¹ Wright State University, Dayton VAMC, Dayton, OH, United States.
¹² Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, United States.
¹³ Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Campus, Maywood, IL, United States.
¹⁴ Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, United States.
¹⁵ Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.
¹⁶ Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Campus, Maywood, IL, United States; Integrative Cell Biology Program, Loyola University Chicago Health Sciences Campus, Maywood, IL, United States.
¹⁷ Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Molecular Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Medical Scientist Training Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; VA Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional Veterans Affairs (VA) Medical Center, Aurora, CO, United States. Electronic address: Elizabeth.Kovacs@CUAnschutz.edu.

PMID: 35659577
PMCID: PMC9994264
DOI: 10.1016/j.alcohol.2022.05.004

Abstract

On November 19th, 2021, the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at Loyola University Chicago Health Sciences Campus in Maywood, Illinois. The 2021 meeting focused on how alcohol misuse is linked to immune system derangements, leading to tissue and organ damage, and how this research can be translated into improving treatment of alcohol-related disease. This meeting was divided into three plenary sessions: the first session focused on how alcohol misuse affects different parts of the immune system, the second session presented research on mechanisms of organ damage from alcohol misuse, and the final session highlighted research on potential therapeutic targets for treating alcohol-mediated tissue damage. Diverse areas of alcohol research were covered during the meeting, from alcohol's effect on pulmonary systems and neuroinflammation to epigenetic changes, senescence markers, and microvesicle particles. These presentations yielded a thoughtful discussion on how the findings can lead to therapeutic treatments for people suffering from alcohol-related diseases.

Keywords: brain; cardiovascular disease; ethanol; inflammation; liver; lung; myopathy; pneumonia; skin; stem cell.

PubMed Disclaimer

References

1. Adler K, Molina PE, & Simon L (2019). Epigenomic mechanisms of alcohol-induced impaired differentiation of skeletal muscle stem cells; role of Class IIA histone deacetylases. Physiological Genomics, 51(9), 471–479. - PMC - PubMed
1. Alfonso-Loeches S, & Guerri C (2011). Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. Critical Reviews in Clinical Laboratory Sciences, 48(1), 19–47. - PubMed
1. Angelova DM, & Brown DR (2019). Microglia and the aging brain: Are senescent microglia the key to neurodegeneration? Journal of Neurochemistry, 151(6), 676–688. - PubMed
1. Aravinthan A, Pietrosi G, Hoare M, Jupp J, Marshall A, Verrill C, et al. (2013). Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease. PLoS One, 8(9), Article e72904. - PMC - PubMed
1. Brenner LA, Forster JE, Stearns-Yoder KA, Stamper CE, Hoisington AJ, Brostow DP, et al. (2020). Evaluation of an immunomodulatory probiotic intervention for veterans with Co-occurring mild traumatic brain injury and posttraumatic stress disorder: A pilot study. Frontiers in Neurology, 11, 1015. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Affiliations

New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical