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Comment
. 2022 Jun 2;29(6):871-872.
doi: 10.1016/j.stem.2022.05.008.

Multicellular dynamics of zonal liver regeneration mapped in space and time

Feng Chen  1 , Jan S Tchorz  2
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Multicellular dynamics of zonal liver regeneration mapped in space and time

Feng Chen et al. Cell Stem Cell. .
Free article

Abstract

In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.

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Conflict of interest statement

Declaration of interests The authors are employed by and are shareholders of Novartis Pharma AG but state no conflict of interest related to this work.

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