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. 2022 Sep;63(3):587-594.
doi: 10.1007/s13353-022-00706-y. Epub 2022 Jun 4.

RNA editing detection in SARS-CoV-2 transcriptome should be different from traditional SNV identification

Houhao Cai  1 , Xiantao Liu  2 , Xin Zheng  3
Affiliations

RNA editing detection in SARS-CoV-2 transcriptome should be different from traditional SNV identification

Houhao Cai et al. J Appl Genet. 2022 Sep.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The bioinformatic software for RNA editing detection and how they differ from the traditional SNP-calling pipeline
Fig. 2
Fig. 2
Schematic diagrams. A The SNP profile which is symmetric. B The RNA editing profile which shows a striking peak at A-to-G
Fig. 3
Fig. 3
If one intends to identify A-to-I and C-to-U editing sites from the same dataset, then one needs to follow the stringent pipelines. Theoretically, one should only regard A > G sites as A-to-I editing. However, this golden standard might be “compromised” if one argues that there is antisense editing on viral RNAs. The same logic goes for C-to-U editing
See this image and copyright information in PMC

References

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