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. 1987 Mar;69(2):48-53.

Experimental colorectal cancer as a model of human disease

J M Gilbert

Experimental colorectal cancer as a model of human disease

J M Gilbert. Ann R Coll Surg Engl. 1987 Mar.

Abstract

Colorectal cancer may now be induced consistently in experimental animals by the carcinogen 1,2-dimethylhydrazine (DMH). Adenomas and adenocarcinomas are produced in the large bowel and these resemble human colorectal cancer both macroscopically, and in their clinical behaviour. They are a close model of human disease and may be used for the evaluation of anti-cancer therapies and for the development of a diagnostic test for colorectal cancer.

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